Immunology Antibodies 1
Anti-CXCR5 Antibody (CAB14233)
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- SKU:
- CAB14233
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Immunology
Description
| Antibody Name: | Anti-CXCR5 Antibody |
| Antibody SKU: | CAB14233 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IF |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 193-372 of human CXCR5 (NP_001707.1). |
| Application: | WB IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse |
| Positive Samples: |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 193-372 of human CXCR5 (NP_001707.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | GHHN NSLP RCTF SQEN QAET HAWF TSRF LYHV AGFL LPML VMGW CYVG VVHR LRQA QRRP QRQK AVRV AILV TSIF FLCW SPYH IVIF LDTL ARLK AVDN TCKL NGSL PVAI TMCE FLGL AHCC LNPM LYTF AGVK FRSD LSRL LTKL GCTG PASL CQLF PSWR RSSL SESE NATS LTTF |
| Gene ID: | 643 |
| Uniprot: | P32302 |
| Cellular Location: | Cell membrane, Multi-pass membrane protein |
| Calculated MW: | 36kDa/41kDa |
| Observed MW: | Refer to Figures |
| Synonyms: | CXCR5, BLR1, CD185, MDR15 |
| Background: | This gene encodes a multi-pass membrane protein that belongs to the CXC chemokine receptor family. It is expressed in mature B-cells and Burkitt's lymphoma. This cytokine receptor binds to B-lymphocyte chemoattractant (BLC), and is involved in B-cell migration into B-cell follicles of spleen and Peyer patches. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. |
| UniProt Protein Function: | CXCR5: Cytokine receptor that binds to B-lymphocyte chemoattractant (BLC). Involved in B-cell migration into B-cell follicles of spleen and Peyer patches but not into those of mesenteric or peripheral lymph nodes. May have a regulatory function in Burkitt lymphoma (BL) lymphomagenesis and/or B-cell differentiation. Belongs to the G-protein coupled receptor 1 family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Receptor, GPCR; GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass Chromosomal Location of Human Ortholog: 11q23.3 Cellular Component: integral to plasma membrane; plasma membrane; external side of plasma membrane Molecular Function:G-protein coupled receptor activity; protein binding; C-X-C chemokine receptor activity Biological Process: positive regulation of cytokinesis; G-protein coupled receptor protein signaling pathway; B cell activation; immune response; cell motility; chemotaxis; lymph node development |
| NCBI Summary: | This gene encodes a multi-pass membrane protein that belongs to the CXC chemokine receptor family. It is expressed in mature B-cells and Burkitt's lymphoma. This cytokine receptor binds to B-lymphocyte chemoattractant (BLC), and is involved in B-cell migration into B-cell follicles of spleen and Peyer patches. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011] |
| UniProt Code: | P32302 |
| NCBI GenInfo Identifier: | 416718 |
| NCBI Gene ID: | 643 |
| NCBI Accession: | P32302.1 |
| UniProt Related Accession: | P32302 |
| Molecular Weight: | |
| NCBI Full Name: | C-X-C chemokine receptor type 5 |
| NCBI Synonym Full Names: | C-X-C motif chemokine receptor 5 |
| NCBI Official Symbol: | CXCR5 |
| NCBI Official Synonym Symbols: | BLR1; CD185; MDR15 |
| NCBI Protein Information: | C-X-C chemokine receptor type 5 |
| UniProt Protein Name: | C-X-C chemokine receptor type 5 |
| UniProt Synonym Protein Names: | Burkitt lymphoma receptor 1; Monocyte-derived receptor 15; MDR-15; CD_antigen: CD185 |
| UniProt Gene Name: | CXCR5 |
| UniProt Entry Name: | CXCR5_HUMAN |
 | Immunofluorescence analysis of U2OS cells using CXCR5 antibody (CAB14233) at dilution of 1:100. Blue: DAPI for nuclear staining. |
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