Cell Biology Antibodies 7

Anti-CXCR1 Antibody (CAB16386)

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SKU:
CAB16386
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-CXCR1 Antibody
Antibody SKU:CAB16386
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 250-350 of human CXCR1 (NP_000625.1).
Application:WB IHC
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:Rat lung, Rat spleen
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 250-350 of human CXCR1 (NP_000625.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:IFLL CWLP YNLV LLAD TLMR TQVI QESC ERRN NIGR ALDA TEIL GFLH SCLN PIIY AFIG QNFR HGFL KILA MHGL VSKE FLAR HRVT SYTS SSVN VSSN L
Gene ID:3577
Uniprot:P25024
Cellular Location:Cell membrane, Multi-pass membrane protein
Calculated MW:39kDa
Observed MW:70kDa
Synonyms:CXCR1, C-C, C-C-CKR-1, CD128, CD181, CDw128a, CKR-1, CMKAR1, IL8R1, IL8RA, IL8RBA
Background:The protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system. Knockout studies in mice suggested that this protein inhibits embryonic oligodendrocyte precursor migration in developing spinal cord. This gene, IL8RB, a gene encoding another high affinity IL8 receptor, as well as IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36.
UniProt Protein Function:IL8RA: Receptor to interleukin-8, which is a powerful neutrophils chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activate a phosphatidylinositol-calcium second messenger system. This receptor binds to IL-8 with a high affinity and to MGSA (GRO) with a low affinity. Belongs to the G-protein coupled receptor 1 family.
UniProt Protein Details:

Protein type:Membrane protein, multi-pass; GPCR, family 1; Membrane protein, integral; Receptor, GPCR; Receptor, cytokine

Chromosomal Location of Human Ortholog: 2q35

Cellular Component: membrane; plasma membrane; integral to membrane

Molecular Function:G-protein coupled receptor activity; interleukin-8 receptor activity; chemokine receptor activity; interleukin-8 binding

Biological Process: G-protein coupled receptor protein signaling pathway; cell surface receptor linked signal transduction; receptor internalization; dendritic cell chemotaxis; chemotaxis; inflammatory response

Disease: Human Immunodeficiency Virus Type 1, Susceptibility To

NCBI Summary:The protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system. Knockout studies in mice suggested that this protein inhibits embryonic oligodendrocyte precursor migration in developing spinal cord. This gene, IL8RB, a gene encoding another high affinity IL8 receptor, as well as IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36. [provided by RefSeq, Jul 2008]
UniProt Code:P25024
NCBI GenInfo Identifier:108936015
NCBI Gene ID:3577
NCBI Accession:P25024.2
UniProt Secondary Accession:P25024,Q2YEF8, Q2YEG4, Q2YEG5, Q2YEG7, Q2YEG8, Q53R18 Q6IN95, Q8N6T6, Q9P2T8, Q9P2T9, B2R6Q3,
UniProt Related Accession:P25024
Molecular Weight:39,791 Da
NCBI Full Name:C-X-C chemokine receptor type 1
NCBI Synonym Full Names:chemokine (C-X-C motif) receptor 1
NCBI Official Symbol:CXCR1  
NCBI Official Synonym Symbols:C-C; CD128; CD181; CKR-1; IL8R1; IL8RA; CMKAR1; IL8RBA; CDw128a; C-C-CKR-1  
NCBI Protein Information:C-X-C chemokine receptor type 1; CXC-R1; CXCR-1; IL-8R A; IL-8 receptor type 1; interleukin 8 receptor, alpha; interleukin-8 receptor type 1; interleukin-8 receptor type A; high affinity interleukin-8 receptor A
UniProt Protein Name:C-X-C chemokine receptor type 1
UniProt Synonym Protein Names:CDw128a; High affinity interleukin-8 receptor A; IL-8R A; IL-8 receptor type 1; CD_antigen: CD181
Protein Family:C-X-C chemokine receptor
UniProt Gene Name:CXCR1  
UniProt Entry Name:CXCR1_HUMAN
Anti-CXCR1 Antibody (CAB16386)Western blot analysis of extracts of various cell lines, using CXCR1 antibody (CAB16386) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 15s.
Anti-CXCR1 Antibody (CAB16386)Immunohistochemistry of paraffin-embedded rat lung using CXCR1 antibody (CAB16386) at dilution of 1:100 (40x lens).
Anti-CXCR1 Antibody (CAB16386)Immunohistochemistry of paraffin-embedded human colon using CXCR1 antibody (CAB16386) at dilution of 1:100 (40x lens).
Anti-CXCR1 Antibody (CAB16386)Immunohistochemistry of paraffin-embedded mouse spleen using CXCR1 antibody (CAB16386) at dilution of 1:100 (40x lens).
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