Cell Biology Antibodies 7
Anti-CXCR1 Antibody (CAB16386)
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- SKU:
- CAB16386
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-CXCR1 Antibody |
| Antibody SKU: | CAB16386 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 250-350 of human CXCR1 (NP_000625.1). |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | Rat lung, Rat spleen |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 250-350 of human CXCR1 (NP_000625.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | IFLL CWLP YNLV LLAD TLMR TQVI QESC ERRN NIGR ALDA TEIL GFLH SCLN PIIY AFIG QNFR HGFL KILA MHGL VSKE FLAR HRVT SYTS SSVN VSSN L |
| Gene ID: | 3577 |
| Uniprot: | P25024 |
| Cellular Location: | Cell membrane, Multi-pass membrane protein |
| Calculated MW: | 39kDa |
| Observed MW: | 70kDa |
| Synonyms: | CXCR1, C-C, C-C-CKR-1, CD128, CD181, CDw128a, CKR-1, CMKAR1, IL8R1, IL8RA, IL8RBA |
| Background: | The protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system. Knockout studies in mice suggested that this protein inhibits embryonic oligodendrocyte precursor migration in developing spinal cord. This gene, IL8RB, a gene encoding another high affinity IL8 receptor, as well as IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36. |
| UniProt Protein Function: | IL8RA: Receptor to interleukin-8, which is a powerful neutrophils chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activate a phosphatidylinositol-calcium second messenger system. This receptor binds to IL-8 with a high affinity and to MGSA (GRO) with a low affinity. Belongs to the G-protein coupled receptor 1 family. |
| UniProt Protein Details: | Protein type:Membrane protein, multi-pass; GPCR, family 1; Membrane protein, integral; Receptor, GPCR; Receptor, cytokine Chromosomal Location of Human Ortholog: 2q35 Cellular Component: membrane; plasma membrane; integral to membrane Molecular Function:G-protein coupled receptor activity; interleukin-8 receptor activity; chemokine receptor activity; interleukin-8 binding Biological Process: G-protein coupled receptor protein signaling pathway; cell surface receptor linked signal transduction; receptor internalization; dendritic cell chemotaxis; chemotaxis; inflammatory response Disease: Human Immunodeficiency Virus Type 1, Susceptibility To |
| NCBI Summary: | The protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system. Knockout studies in mice suggested that this protein inhibits embryonic oligodendrocyte precursor migration in developing spinal cord. This gene, IL8RB, a gene encoding another high affinity IL8 receptor, as well as IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P25024 |
| NCBI GenInfo Identifier: | 108936015 |
| NCBI Gene ID: | 3577 |
| NCBI Accession: | P25024.2 |
| UniProt Secondary Accession: | P25024,Q2YEF8, Q2YEG4, Q2YEG5, Q2YEG7, Q2YEG8, Q53R18 Q6IN95, Q8N6T6, Q9P2T8, Q9P2T9, B2R6Q3, |
| UniProt Related Accession: | P25024 |
| Molecular Weight: | 39,791 Da |
| NCBI Full Name: | C-X-C chemokine receptor type 1 |
| NCBI Synonym Full Names: | chemokine (C-X-C motif) receptor 1 |
| NCBI Official Symbol: | CXCR1 |
| NCBI Official Synonym Symbols: | C-C; CD128; CD181; CKR-1; IL8R1; IL8RA; CMKAR1; IL8RBA; CDw128a; C-C-CKR-1 |
| NCBI Protein Information: | C-X-C chemokine receptor type 1; CXC-R1; CXCR-1; IL-8R A; IL-8 receptor type 1; interleukin 8 receptor, alpha; interleukin-8 receptor type 1; interleukin-8 receptor type A; high affinity interleukin-8 receptor A |
| UniProt Protein Name: | C-X-C chemokine receptor type 1 |
| UniProt Synonym Protein Names: | CDw128a; High affinity interleukin-8 receptor A; IL-8R A; IL-8 receptor type 1; CD_antigen: CD181 |
| Protein Family: | C-X-C chemokine receptor |
| UniProt Gene Name: | CXCR1 |
| UniProt Entry Name: | CXCR1_HUMAN |
 | Western blot analysis of extracts of various cell lines, using CXCR1 antibody (CAB16386) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 15s. |
 | Immunohistochemistry of paraffin-embedded rat lung using CXCR1 antibody (CAB16386) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded human colon using CXCR1 antibody (CAB16386) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded mouse spleen using CXCR1 antibody (CAB16386) at dilution of 1:100 (40x lens). |
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