Cell Biology Antibodies 12
Anti-CXCL14 Antibody (CAB9857)
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- SKU:
- CAB9857
- Product Type:
- Antibody
- Applications:
- WB
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-CXCL14 Antibody |
| Antibody SKU: | CAB9857 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 35-111 of human CXCL14 (NP_004878.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: | NCI-H460 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 35-111 of human CXCL14 (NP_004878.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | SKCK CSRK GPKI RYSD VKKL EMKP KYPH CEEK MVII TTKS VSRY RGQE HCLH PKLQ STKR FIKW YNAW NEKR RVYE E |
| Gene ID: | 9547 |
| Uniprot: | O95715 |
| Cellular Location: | Secreted |
| Calculated MW: | 13kDa |
| Observed MW: | 13kDa |
| Synonyms: | CXCL14, BMAC, BRAK, KEC, KS1, MIP-2g, MIP2G, NJAC, SCYB14 |
| Background: | This antimicrobial gene belongs to the cytokine gene family which encode secreted proteins involved in immunoregulatory and inflammatory processes. The protein encoded by this gene is structurally related to the CXC (Cys-X-Cys) subfamily of cytokines. Members of this subfamily are characterized by two cysteines separated by a single amino acid. This cytokine displays chemotactic activity for monocytes but not for lymphocytes, dendritic cells, neutrophils or macrophages. It has been implicated that this cytokine is involved in the homeostasis of monocyte-derived macrophages rather than in inflammation. |
| UniProt Protein Function: | CXCL14: Potent chemoattractant for neutrophils, and weaker for dendritic cells. Not chemotactic for T-cells, B-cells, monocytes, natural killer cells or granulocytes. Does not inhibit proliferation of myeloid progenitors in colony formation assays. Belongs to the intercrine alpha (chemokine CxC) family. |
| UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; Secreted; Chemokine; Secreted, signal peptide Chromosomal Location of Human Ortholog: 5q31 Cellular Component: Golgi apparatus; extracellular space Molecular Function:chemokine activity Biological Process: cell-cell signaling; immune response; negative regulation of myoblast differentiation; chemotaxis; signal transduction; inner ear development |
| NCBI Summary: | This antimicrobial gene belongs to the cytokine gene family which encode secreted proteins involved in immunoregulatory and inflammatory processes. The protein encoded by this gene is structurally related to the CXC (Cys-X-Cys) subfamily of cytokines. Members of this subfamily are characterized by two cysteines separated by a single amino acid. This cytokine displays chemotactic activity for monocytes but not for lymphocytes, dendritic cells, neutrophils or macrophages. It has been implicated that this cytokine is involved in the homeostasis of monocyte-derived macrophages rather than in inflammation. [provided by RefSeq, Sep 2014] |
| UniProt Code: | O95715 |
| NCBI GenInfo Identifier: | 292495003 |
| NCBI Gene ID: | 9547 |
| NCBI Accession: | O95715.2 |
| UniProt Secondary Accession: | O95715,Q6UW97, Q86U69, Q9BTR1, Q9NS21, B3KQU8, |
| UniProt Related Accession: | O95715 |
| Molecular Weight: | 13,078 Da |
| NCBI Full Name: | C-X-C motif chemokine 14 |
| NCBI Synonym Full Names: | chemokine (C-X-C motif) ligand 14 |
| NCBI Official Symbol: | CXCL14 |
| NCBI Official Synonym Symbols: | KEC; KS1; BMAC; BRAK; NJAC; MIP2G; MIP-2g; SCYB14 |
| NCBI Protein Information: | C-X-C motif chemokine 14; bolekine; MIP-2 gamma; chemokine BRAK; breast and kidney; tumor-suppressing chemokine; small-inducible cytokine B14; CXC chemokine in breast and kidney; small inducible cytokine subfamily B (Cys-X-Cys), member 14 (BRAK) |
| UniProt Protein Name: | C-X-C motif chemokine 14 |
| UniProt Synonym Protein Names: | Chemokine BRAK; MIP-2G; Small-inducible cytokine B14 |
| UniProt Gene Name: | CXCL14 |
| UniProt Entry Name: | CXL14_HUMAN |
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