Immunology Antibodies 2
Anti-CX3CR1 Antibody (CAB2890)
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- SKU:
- CAB2890
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Immunology
Description
| Antibody Name: | Anti-CX3CR1 Antibody |
| Antibody SKU: | CAB2890 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide of human CX3CR1 |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | Mouse fetal muscle |
| Immunogen: | A synthetic peptide of human CX3CR1 |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 1524 |
| Uniprot: | P49238 |
| Cellular Location: | Cell membrane, Multi-pass membrane protein |
| Calculated MW: | 40kDa/41kDa/43kDa |
| Observed MW: | 55kDa |
| Synonyms: | CX3CR1, CCRL1, CMKBRL1, CMKDR1, GPR13, GPRV28, V28 |
| Background: | Fractalkine is a transmembrane protein and chemokine involved in the adhesion and migration of leukocytes. The protein encoded by this gene is a receptor for fractalkine. The encoded protein also is a coreceptor for HIV-1, and some variations in this gene lead to increased susceptibility to HIV-1 infection and rapid progression to AIDS. Four transcript variants encoding two different isoforms have been found for this gene. |
| UniProt Protein Function: | CX3CR1: Receptor for the CX3C chemokine fractalkine and mediates both its adhesive and migratory functions. Acts as coreceptor with CD4 for HIV-1 virus envelope protein (in vitro). Isoform 2 and isoform 3 seem to be more potent HIV-1 coreceptors than isoform 1. Defects in CX3CR1 are a cause of susceptibility to age- related macular degeneration type 12 (ARMD12). ARMD12 is a form of age-related macular degeneration, a multifactorial eye disease and the most common cause of irreversible vision loss in the developed world. In most patients, the disease is manifest as ophthalmoscopically visible yellowish accumulations of protein and lipid that lie beneath the retinal pigment epithelium and within an elastin-containing structure known as Bruch membrane. Belongs to the G-protein coupled receptor 1 family. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; Membrane protein, integral; Receptor, GPCR; Receptor, cytokine; GPCR, family 1; Cell adhesion; Membrane protein, multi-pass Chromosomal Location of Human Ortholog: 3p21.3 Cellular Component: neuron projection; perinuclear region of cytoplasm; integral to plasma membrane; plasma membrane Molecular Function:protein binding; chemokine receptor activity; C-X3-C chemokine receptor activity Biological Process: G-protein coupled receptor protein signaling pathway; positive regulation of angiogenesis; negative regulation of angiogenesis; cerebral cortex cell migration; viral reproduction; response to wounding; cellular defense response; chemotaxis; cell adhesion; negative regulation of cell migration; macrophage chemotaxis; microglial cell activation during immune response Disease: Macular Degeneration, Age-related, 12; Coronary Heart Disease, Susceptibility To, 1; Human Immunodeficiency Virus Type 1, Susceptibility To |
| NCBI Summary: | Fractalkine is a transmembrane protein and chemokine involved in the adhesion and migration of leukocytes. The protein encoded by this gene is a receptor for fractalkine. The encoded protein also is a coreceptor for HIV-1, and some variations in this gene lead to increased susceptibility to HIV-1 infection and rapid progression to AIDS. Four transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jan 2010] |
| UniProt Code: | P49238 |
| NCBI GenInfo Identifier: | 1351394 |
| NCBI Gene ID: | 1524 |
| NCBI Accession: | P49238.1 |
| UniProt Secondary Accession: | P49238,A0N0N6, B2R5Z4, J3KP17, |
| UniProt Related Accession: | P49238 |
| Molecular Weight: | 43,969 Da |
| NCBI Full Name: | CX3C chemokine receptor 1 |
| NCBI Synonym Full Names: | chemokine (C-X3-C motif) receptor 1 |
| NCBI Official Symbol: | CX3CR1 |
| NCBI Official Synonym Symbols: | V28; CCRL1; GPR13; CMKDR1; GPRV28; CMKBRL1 |
| NCBI Protein Information: | CX3C chemokine receptor 1; CMK-BRL1; CMK-BRL-1; C-X3-C CKR-1; fractalkine receptor; G protein-coupled receptor 13; G-protein coupled receptor 13; chemokine (C-X3-C) receptor 1; beta chemokine receptor-like 1; chemokine (C-C) receptor-like 1 |
| UniProt Protein Name: | CX3C chemokine receptor 1 |
| UniProt Synonym Protein Names: | Beta chemokine receptor-like 1; CMK-BRL-1; CMK-BRL1; Fractalkine receptor; G-protein coupled receptor 13; V28 |
| Protein Family: | CX3C chemokine receptor |
| UniProt Gene Name: | CX3CR1 |
| UniProt Entry Name: | CX3C1_HUMAN |
 | Western blot analysis of extracts of mouse fetal muscle, using CX3CR1 antibody (CAB2890). Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. |
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