Immunology Antibodies 2
Anti-CUL5 Antibody (CAB5369)
- SKU:
- CAB5369
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Immunology
Description
| Antibody Name: | Anti-CUL5 Antibody |
| Antibody SKU: | CAB5369 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IF |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human CUL5 (NP_003469.2). |
| Application: | WB IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse |
| Positive Samples: | 293T, PC-3, Mouse heart, Mouse gastrocnemius muscle |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human CUL5 (NP_003469.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MATS NLLK NKGS LQFE DKWD FMRP IVLK LLRQ ESVT KQQW FDLF SDVH AVCL WDDK GPAK IHQA LKED ILEF IKQA QARV LSHQ DDTA LLKA YIVE WRKF FTQC DILP KPFC QLEI TLMG KQGS NKKS NVED SIVR KLML DTWN ESIF SNIK NRLQ DSAM KLVH AERL GEAF DSQL VIGV RESY VNLC SNPE DKLQ IYRD NFEK AYLD STER FYRT QAPS YLQQ NGVQ NYMK YADA KLKE EEKR ALRY LETR RECN SVEA LMEC CVNA LVTS FKET ILAE CQGM IKRN ETEK LHLM FSLM |
| Gene ID: | 8065 |
| Uniprot: | Q93034 |
| Cellular Location: | |
| Calculated MW: | 90kDa |
| Observed MW: | 91kDa |
| Synonyms: | CUL5, CUL-5, VACM-1, VACM1, cullin-5 |
| Background: |
| UniProt Protein Function: | CUL5: a component of E3 ubiquitin ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to be involved proteasomal degradation of p53/TP53 stimulated by adenovirus E1B-55 kDa protein. Member of the cullin family. |
| UniProt Protein Details: | Protein type:Ubiquitin conjugating system Chromosomal Location of Human Ortholog: 11q22.3 Cellular Component: Cul5-RING ubiquitin ligase complex; cytosol Molecular Function:calcium channel activity; protein binding; receptor activity; ubiquitin protein ligase binding; ubiquitin-protein ligase activity Biological Process: cell cycle arrest; cell proliferation; G1/S transition of mitotic cell cycle; negative regulation of cell proliferation; protein ubiquitination during ubiquitin-dependent protein catabolic process |
| UniProt Code: | Q93034 |
| NCBI GenInfo Identifier: | 14917099 |
| NCBI Gene ID: | 8065 |
| NCBI Accession: | Q93034.4 |
| UniProt Secondary Accession: | Q93034,O14766, Q9BZC6, A8K960, |
| UniProt Related Accession: | Q93034 |
| Molecular Weight: | 90,955 Da |
| NCBI Full Name: | Cullin-5 |
| NCBI Synonym Full Names: | cullin 5 |
| NCBI Official Symbol: | CUL5 |
| NCBI Official Synonym Symbols: | VACM1; VACM-1 |
| NCBI Protein Information: | cullin-5 |
| UniProt Protein Name: | Cullin-5 |
| UniProt Synonym Protein Names: | Vasopressin-activated calcium-mobilizing receptor 1; VACM-1 |
| Protein Family: | Cullin |
| UniProt Gene Name: | CUL5 |
| UniProt Entry Name: | CUL5_HUMAN |
 | Western blot analysis of extracts of various cell lines, using CUL5 Antibody (CAB5369) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
 | Immunofluorescence analysis of U2OS cells using CUL5 antibody (CAB5369). Blue: DAPI for nuclear staining. |
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