Signal Transduction Antibodies 1
Anti-CUEDC2 Antibody (CAB13914)
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- SKU:
- CAB13914
- Product Type:
- Antibody
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Description
| Antibody Name: | Anti-CUEDC2 Antibody |
| Antibody SKU: | CAB13914 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-150 of human CUEDC2 (NP_076945.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Rat |
| Positive Samples: | Rat lung |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-150 of human CUEDC2 (NP_076945.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MELE RIVS AALL AFVQ THLP EADL SGLD EVIF SYVL GVLE DLGP SGPS EENF DMEA FTEM MEAY VPGF AHIP RGTI GDMM QKLS GQLS DARN KENL QPQS SGVQ GQVP ISPE PLQR PEML KEET RSSA AAAA DTQD EATG AEEE LLPG VD |
| Gene ID: | 79004 |
| Uniprot: | Q9H467 |
| Cellular Location: | Cytoplasm, Nucleus |
| Calculated MW: | 32kDa |
| Observed MW: | 32kDa |
| Synonyms: | CUEDC2, C10orf66, bA18I14.5 |
| Background: |
| UniProt Protein Function: | CUEDC2: Down-regulates ESR1 protein levels through the ubiquitination-proteasome pathway, regardless of the presence of 17 beta-estradiol. Also involved in 17 beta-estradiol-induced ESR1 degradation. Controls PGR protein levels through a similar mechanism. May predict the clinical outcome of tamoxifen therapy of breast cancer patients. Patients with tumors that highly express CUEDC2 do not respond to tamoxifen treatment as effectively as those with tumors with low expression. Belongs to the CUEDC2 family. |
| UniProt Protein Details: | Chromosomal Location of Human Ortholog: 10q24.32 Cellular Component: cytoplasm; nuclear membrane; nucleoplasm Molecular Function:protein binding |
| UniProt Code: | Q9H467 |
| NCBI GenInfo Identifier: | 74752634 |
| NCBI Gene ID: | 79004 |
| NCBI Accession: | Q9H467.1 |
| UniProt Secondary Accession: | Q9H467,Q9BWG8, D3DR88, |
| UniProt Related Accession: | Q9H467 |
| Molecular Weight: | 32,009 Da |
| NCBI Full Name: | CUE domain-containing protein 2 |
| NCBI Synonym Full Names: | CUE domain containing 2 |
| NCBI Official Symbol: | CUEDC2 |
| NCBI Official Synonym Symbols: | C10orf66; bA18I14.5 |
| NCBI Protein Information: | CUE domain-containing protein 2 |
| UniProt Protein Name: | CUE domain-containing protein 2 |
| Protein Family: | CUE domain-containing protein |
| UniProt Gene Name: | CUEDC2 |
| UniProt Entry Name: | CUED2_HUMAN |
 | Western blot analysis of extracts of rat lung, using CUEDC2 antibody (CAB13914) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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