Cell Biology Antibodies 8

Anti-CTSZ Antibody (CAB2681)

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SKU:
CAB2681
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology

Description

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Antibody Name:Anti-CTSZ Antibody
Antibody SKU:CAB2681
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-303 of human CTSZ (NP_001327.2).
Application:WB
Recommended Dilution:WB 1:1000 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:SKOV3, 22Rv1, SW480, THP-1, HeLa, Mouse kidney, Mouse liver, Rat thymus
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-303 of human CTSZ (NP_001327.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MARR GPGW RPLL LLVL LAGA AQGG LYFR RGQT CYRP LRGD GLAP LGRS TYPR PHEY LSPA DLPK SWDW RNVD GVNY ASIT RNQH IPQY CGSC WAHA STSA MADR INIK RKGA WPST LLSV QNVI DCGN AGSC EGGN DLSV WDYA HQHG IPDE TCNN YQAK DQEC DKFN QCGT CNEF KECH AIRN YTLW RVGD YGSL SGRE KMMA EIYA NGPI SCGI MATE RLAN YTGG IYAE YQDT TYIN HVVS VAGW GISD GTEY WIVR NSWG EPWG ERGW LRIV TSTY KDGK GARY NLAI EEHC TFGD PIV
Gene ID:1522
Uniprot:Q9UBR2
Cellular Location:Lysosome
Calculated MW:33kDa
Observed MW:36kDa
Synonyms:CTSZ, CTSX
Background:The protein encoded by this gene is a lysosomal cysteine proteinase and member of the peptidase C1 family. It exhibits both carboxy-monopeptidase and carboxy-dipeptidase activities. The encoded protein has also been known as cathepsin X and cathepsin P. This gene is expressed ubiquitously in cancer cell lines and primary tumors and, like other members of this family, may be involved in tumorigenesis.
UniProt Protein Function:CTSZ: Exhibits carboxy-monopeptidase as well as carboxy- dipeptidase activity. Belongs to the peptidase C1 family.
UniProt Protein Details:

Protein type:EC 3.4.18.1; Protease

Chromosomal Location of Human Ortholog: 20q13.32

Cellular Component: extracellular space; intracellular membrane-bound organelle; lysosome; endoplasmic reticulum; plasma membrane

Molecular Function:cysteine-type peptidase activity

Biological Process: cellular protein metabolic process; angiotensin maturation; proteolysis

Disease: Mycobacterium Tuberculosis, Susceptibility To

NCBI Summary:The protein encoded by this gene is a lysosomal cysteine proteinase and member of the peptidase C1 family. It exhibits both carboxy-monopeptidase and carboxy-dipeptidase activities. The encoded protein has also been known as cathepsin X and cathepsin P. This gene is expressed ubiquitously in cancer cell lines and primary tumors and, like other members of this family, may be involved in tumorigenesis. [provided by RefSeq, Oct 2008]
UniProt Code:Q9UBR2
NCBI GenInfo Identifier:12643324
NCBI Gene ID:1522
NCBI Accession:Q9UBR2.1
UniProt Secondary Accession:Q9UBR2,O75331, Q9UQV5, Q9UQV6, B2RC40,
UniProt Related Accession:Q9UBR2
Molecular Weight:303
NCBI Full Name:Cathepsin Z
NCBI Synonym Full Names:cathepsin Z
NCBI Official Symbol:CTSZ  
NCBI Official Synonym Symbols:CTSX  
NCBI Protein Information:cathepsin Z; cathepsin P; cathepsin X; cathepsin Y; cathepsin B2; cathepsin IV; cathepsin Z1; preprocathepsin P; carboxypeptidase LB; lysosomal carboxypeptidase B; cysteine-type carboxypeptidase
UniProt Protein Name:Cathepsin Z
UniProt Synonym Protein Names:Cathepsin P; Cathepsin X
Protein Family:Cathepsin
UniProt Gene Name:CTSZ  
UniProt Entry Name:CATZ_HUMAN
Anti-CTSZ Antibody (CAB2681)Western blot analysis of extracts of various cell lines, using CTSZ antibody (CAB2681) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s.
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