Cell Biology Antibodies 7

Anti-CTSS Antibody (CAB1874)

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SKU:
CAB1874
Product Type:
Antibody
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology

Description

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Antibody Name:Anti-CTSS Antibody
Antibody SKU:CAB1874
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 115-331 of human CTSS (NP_004070.3).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Mouse
Positive Samples:Mouse liver
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 115-331 of human CTSS (NP_004070.3).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:LPDS VDWR EKGC VTEV KYQG SCGA CWAF SAVG ALEA QLKL KTGK LVSL SAQN LVDC STEK YGNK GCNG GFMT TAFQ YIID NKGI DSDA SYPY KAMD QKCQ YDSK YRAA TCSK YTEL PYGR EDVL KEAV ANKG PVSV GVDA RHPS FFLY RSGV YYEP SCTQ NVNH GVLV VGYG DLNG KEYW LVKN SWGH NFGE EGYI RMAR NKGN HCGI ASFP SYPE I
Gene ID:1520
Uniprot:P25774
Cellular Location:Lysosome
Calculated MW:31kDa/37kDa
Observed MW:36kDa
Synonyms:CTSS
Background:The protein encoded by this gene, a member of the peptidase C1 family, is a lysosomal cysteine proteinase that may participate in the degradation of antigenic proteins to peptides for presentation on MHC class II molecules. The encoded protein can function as an elastase over a broad pH range in alveolar macrophages. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
UniProt Protein Function:CTSS: Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II molecules. The bond- specificity of this proteinase is in part similar to the specificities of cathepsin L and cathepsin N. Belongs to the peptidase C1 family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Protease; EC 3.4.22.27

Chromosomal Location of Human Ortholog: 1q21

Cellular Component: extracellular region; extracellular space; intracellular membrane-bound organelle; lysosomal lumen; lysosome

Molecular Function:collagen binding; cysteine-type endopeptidase activity; fibronectin binding; laminin binding; proteoglycan binding; serine-type endopeptidase activity

Biological Process: adaptive immune response; antigen processing and presentation; antigen processing and presentation of exogenous peptide antigen via MHC class II; antigen processing and presentation of peptide antigen; collagen catabolic process; extracellular matrix disassembly; immune response; protein processing; proteolysis; proteolysis involved in cellular protein catabolic process; response to acidity; toll-like receptor signaling pathway

NCBI Summary:The protein encoded by this gene, a member of the peptidase C1 family, is a lysosomal cysteine proteinase that may participate in the degradation of antigenic proteins to peptides for presentation on MHC class II molecules. The encoded protein can function as an elastase over a broad pH range in alveolar macrophages. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Dec 2010]
UniProt Code:P25774
NCBI GenInfo Identifier:88984046
NCBI Gene ID:1520
NCBI Accession:P25774.3
UniProt Secondary Accession:P25774,Q5T5I0, Q6FHS5, Q9BUG3, B4DWC9, D3DV05,
UniProt Related Accession:P25774
Molecular Weight:31,626 Da
NCBI Full Name:Cathepsin S
NCBI Synonym Full Names:cathepsin S
NCBI Official Symbol:CTSS  
NCBI Protein Information:cathepsin S
UniProt Protein Name:Cathepsin S
Protein Family:Cathepsin
UniProt Gene Name:CTSS  
UniProt Entry Name:CATS_HUMAN
Anti-CTSS Antibody (CAB1874)Western blot analysis of extracts of mouse liver, using CTSS antibody (CAB1874) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST.
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