Cell Biology Antibodies 7
Anti-CTSK Antibody (CAB1782)
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- SKU:
- CAB1782
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-CTSK Antibody |
| Antibody SKU: | CAB1782 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 115-329 of human CTSK (NP_000387.1). |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:100 |
| Reactivity: | Mouse, Rat |
| Positive Samples: | Mouse liver |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 115-329 of human CTSK (NP_000387.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | APDS VDYR KKGY VTPV KNQG QCGS CWAF SSVG ALEG QLKK KTGK LLNL SPQN LVDC VSEN DGCG GGYM TNAF QYVQ KNRG IDSE DAYP YVGQ EESC MYNP TGKA AKCR GYRE IPEG NEKA LKRA VARV GPVS VAID ASLT SFQF YSKG VYYD ESCN SDNL NHAV LAVG YGIQ KGNK HWII KNSW GENW GNKG YILM ARNK NNAC GIAN LASF PKM |
| Gene ID: | 1513 |
| Uniprot: | P43235 |
| Cellular Location: | Lysosome |
| Calculated MW: | 36kDa |
| Observed MW: | 41kDa |
| Synonyms: | CTSK, CTS02, CTSO, CTSO1, CTSO2, PKND, PYCD |
| Background: | The protein encoded by this gene is a lysosomal cysteine proteinase involved in bone remodeling and resorption. This protein, which is a member of the peptidase C1 protein family, is predominantly expressed in osteoclasts. However, the encoded protein is also expressed in a significant fraction of human breast cancers, where it could contribute to tumor invasiveness. Mutations in this gene are the cause of pycnodysostosis, an autosomal recessive disease characterized by osteosclerosis and short stature. |
| UniProt Protein Function: | CTSK: Closely involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation. Defects in CTSK are the cause of pycnodysostosis (PKND). PKND is an autosomal recessive osteochondrodysplasia characterized by osteosclerosis and short stature. Belongs to the peptidase C1 family. |
| UniProt Protein Details: | Protein type:Protease; EC 3.4.22.38 Chromosomal Location of Human Ortholog: 1q21 Cellular Component: extracellular region; extracellular space; lysosome Molecular Function:collagen binding; cysteine-type endopeptidase activity; cysteine-type peptidase activity; fibronectin binding; protein binding; proteoglycan binding; serine-type endopeptidase activity Biological Process: collagen catabolic process; extracellular matrix disassembly; proteolysis; proteolysis involved in cellular protein catabolic process; toll-like receptor signaling pathway Disease: Pycnodysostosis |
| NCBI Summary: | The protein encoded by this gene is a lysosomal cysteine proteinase involved in bone remodeling and resorption. This protein, which is a member of the peptidase C1 protein family, is predominantly expressed in osteoclasts. However, the encoded protein is also expressed in a significant fraction of human breast cancers, where it could contribute to tumor invasiveness. Mutations in this gene are the cause of pycnodysostosis, an autosomal recessive disease characterized by osteosclerosis and short stature. [provided by RefSeq, Apr 2013] |
| UniProt Code: | P43235 |
| NCBI GenInfo Identifier: | 1168793 |
| NCBI Gene ID: | 1513 |
| NCBI Accession: | P43235.1 |
| UniProt Secondary Accession: | P43235,Q6FHS6, |
| UniProt Related Accession: | P43235 |
| Molecular Weight: | 36,966 Da |
| NCBI Full Name: | Cathepsin K |
| NCBI Synonym Full Names: | cathepsin K |
| NCBI Official Symbol: | CTSK |
| NCBI Official Synonym Symbols: | CTSO; PKND; PYCD; CTS02; CTSO1; CTSO2 |
| NCBI Protein Information: | cathepsin K |
| UniProt Protein Name: | Cathepsin K |
| UniProt Synonym Protein Names: | Cathepsin O; Cathepsin O2; Cathepsin X |
| Protein Family: | Cathepsin |
| UniProt Gene Name: | CTSK |
| UniProt Entry Name: | CATK_HUMAN |
 | Western blot analysis of extracts of mouse liver, using CTSK antibody (CAB1782) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
 | Immunohistochemistry of paraffin-embedded mouse brain using CTSK antibody (CAB1782) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded rat brain using CTSK antibody (CAB1782) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded mouse lung using CTSK antibody (CAB1782) at dilution of 1:100 (40x lens). |
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