Cell Biology Antibodies 18
Anti-CTPS2 Antibody (CAB18255)
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- SKU:
- CAB18255
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-CTPS2 Antibody |
| Antibody SKU: | CAB18255 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant protein of human CTPS2. |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: |
| Immunogen: | Recombinant protein of human CTPS2. |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 56474 |
| Uniprot: | Q9NRF8 |
| Cellular Location: | |
| Calculated MW: | 65kDa |
| Observed MW: | Refer to figures |
| Synonyms: | CTPS2 |
| Background: | The protein encoded by this gene catalyzes the formation of CTP from UTP with the concomitant deamination of glutamine to glutamate. This protein is the rate-limiting enzyme in the synthesis of cytosine nucleotides, which play an important role in various metabolic processes and provide the precursors necessary for the synthesis of RNA and DNA. Cancer cells that exhibit increased cell proliferation also exhibit an increased activity of this encoded protein. Thus, this protein is an attractive target for selective chemotherapy. Alternative splicing results in multiple transcript variants. |
| UniProt Protein Function: | CTPS2: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Constitutes the rate-limiting enzyme in the synthesis of cytosine nucleotides. Belongs to the CTP synthase family. |
| UniProt Protein Details: | Protein type:EC 6.3.4.2; Nucleotide Metabolism - pyrimidine; Ligase Chromosomal Location of Human Ortholog: Xp22 Cellular Component: cytosol Molecular Function:CTP synthase activity; protein binding Biological Process: nucleobase, nucleoside and nucleotide interconversion; pyrimidine nucleotide metabolic process |
| NCBI Summary: | The protein encoded by this gene catalyzes the formation of CTP from UTP with the concomitant deamination of glutamine to glutamate. This protein is the rate-limiting enzyme in the synthesis of cytosine nucleotides, which play an important role in various metabolic processes and provide the precursors necessary for the synthesis of RNA and DNA. Cancer cells that exhibit increased cell proliferation also exhibit an increased activity of this encoded protein. Thus, this protein is an attractive target for selective chemotherapy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013] |
| UniProt Code: | Q9NRF8 |
| NCBI GenInfo Identifier: | 74752919 |
| NCBI Gene ID: | 56474 |
| NCBI Accession: | Q9NRF8.1 |
| UniProt Secondary Accession: | Q9NRF8,Q9BRI0, Q9H809, Q9H8K9, B3KWM2, |
| UniProt Related Accession: | Q9NRF8 |
| Molecular Weight: | 65,678 Da |
| NCBI Full Name: | CTP synthase 2 |
| NCBI Synonym Full Names: | CTP synthase 2 |
| NCBI Official Symbol: | CTPS2 |
| NCBI Protein Information: | CTP synthase 2 |
| UniProt Protein Name: | CTP synthase 2 |
| UniProt Synonym Protein Names: | CTP synthetase 2; UTP--ammonia ligase 2 |
| Protein Family: | CTP synthase |
| UniProt Gene Name: | CTPS2 |
| UniProt Entry Name: | PYRG2_HUMAN |
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