Immunology Antibodies 2
Anti-CTPS1 Antibody (CAB3817)
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- SKU:
- CAB3817
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Immunology
Description
| Antibody Name: | Anti-CTPS1 Antibody |
| Antibody SKU: | CAB3817 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 402-591 of human CTPS1 (NP_001896.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse |
| Positive Samples: | Raji, HeLa, 22Rv1, Jurkat, Mouse brain |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 402-591 of human CTPS1 (NP_001896.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MQLA VVEF SRNV LGWQ DANS TEFD PTTS HPVV VDMP EHNP GQMG GTMR LGKR RTLF QTKN SVMR KLYG DADY LEER HRHR FEVN PVWK KCLE EQGL KFVG QDVE GERM EIVE LEDH PFFV GVQY HPEF LSRP IKPS PPYF GLLL ASVG RLSH YLQK GCRL SPRD TYSD RSGS SSPD SEIT ELKF PSIN HD |
| Gene ID: | 1503 |
| Uniprot: | P17812 |
| Cellular Location: | |
| Calculated MW: | 41kDa/66kDa |
| Observed MW: | 80kDa |
| Synonyms: | CTPS1, CTPS, GATD5, IMD24 |
| Background: | This gene encodes an enzyme responsible for the catalytic conversion of UTP (uridine triphosphate) to CTP (cytidine triphospate). This reaction is an important step in the biosynthesis of phospholipids and nucleic acids. Activity of this proten is important in the immune system, and loss of function of this gene has been associated with immunodeficiency. Alternative splicing results in multiple transcript variants. |
| UniProt Protein Function: | CTPS: the enzyme cytidine-5-prime-triphosphate synthetase converts UTP to CTP. Important in the biosynthesis of phospholipids and nucleic acids, and plays a key role in cell growth, development, and tumorigenesis. The region to which the CTPS gene has been mapped is the location of breakpoints involved in several tumor types. |
| UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; EC 6.3.4.2; Nucleotide Metabolism - pyrimidine; Ligase Chromosomal Location of Human Ortholog: 1p34.1 Cellular Component: membrane; cytosol Molecular Function:CTP synthase activity; ATP binding Biological Process: T cell proliferation; B cell proliferation; response to drug; CTP biosynthetic process; nucleobase, nucleoside and nucleotide metabolic process; nucleobase, nucleoside and nucleotide interconversion; nucleobase, nucleoside, nucleotide and nucleic acid metabolic process; glutamine metabolic process Disease: Immunodeficiency 24 |
| NCBI Summary: | This gene encodes an enzyme responsible for the catalytic conversion of UTP (uridine triphosphate) to CTP (cytidine triphospate). This reaction is an important step in the biosynthesis of phospholipids and nucleic acids. Activity of this proten is important in the immune system, and loss of function of this gene has been associated with immunodeficiency. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014] |
| UniProt Code: | P17812 |
| NCBI GenInfo Identifier: | 20981706 |
| NCBI Gene ID: | 1503 |
| NCBI Accession: | P17812.2 |
| UniProt Related Accession: | P17812 |
| Molecular Weight: | ~ 67kDa |
| NCBI Full Name: | CTP synthase 1 |
| NCBI Synonym Full Names: | CTP synthase 1 |
| NCBI Official Symbol: | CTPS1 |
| NCBI Official Synonym Symbols: | CTPS; GATD5; IMD24 |
| NCBI Protein Information: | CTP synthase 1 |
| UniProt Protein Name: | CTP synthase 1 |
| UniProt Synonym Protein Names: | CTP synthetase 1; UTP--ammonia ligase 1 |
| UniProt Gene Name: | CTPS1 |
| UniProt Entry Name: | PYRG1_HUMAN |
 | Western blot analysis of extracts of various cell lines, using CTPS1 antibody (CAB3817) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 5s. |
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