Cell Death Antibodies 2

Anti-CTNNBL1 Antibody (CAB6572)

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SKU:
CAB6572
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Death

Description

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Antibody Name:Anti-CTNNBL1 Antibody
Antibody SKU:CAB6572
Antibody Size:20uL, 50uL, 100uL
Application:WB IF
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 264-563 of human CTNNBL1 (NP_110517.2).
Application:WB IF
Recommended Dilution:WB 1:500 - 1:2000 IF 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:Jurkat, HeLa, SW620, HepG2, Mouse thymus, Rat brain
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 264-563 of human CTNNBL1 (NP_110517.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:EVLA ILLQ DNDE NREL LGEL DGID VLLQ QLSV FKRH NPST AEEQ EMME NLFD SLCS CLML SSNR ERFL KGEG LQLM NLML REKK ISRS SALK VLDH AMIG PEGT DNCH KFVD ILGL RTIF PLFM KSPR KIKK VGTT EKEH EEHV CSIL ASLL RNLR GQQR TRLL NKFT ENDS EKVD RLME LHFK YLGA MQVA DKKI EGEK HDMV RRGE IIDN DTEE EFYL RRLD AGLF VLQH ICYI MAEI CNAN VPQI RQRV HQIL NMRG SSIK IVRH IIKE YAEN IGDG RSPE FREN EQKR ILGL LENF
Gene ID:56259
Uniprot:Q8WYA6
Cellular Location:Cytoplasm, Nucleus
Calculated MW:36kDa/43kDa/61kDa/65kDa
Observed MW:70kDa
Synonyms:CTNNBL1, C20orf33, NAP, P14L, PP8304, dJ633O20.1
Background:The protein encoded by this gene is a component of the pre-mRNA-processing factor 19-cell division cycle 5-like (PRP19-CDC5L) protein complex, which activates pre-mRNA splicing and is an integral part of the spliceosome. The encoded protein is also a nuclear localization sequence binding protein, and binds to activation-induced deaminase and is important for antibody diversification. This gene may also be associated with the development of obesity. Alternative splicing results in multiple transcript variants. A pseudogene of this gene has been defined on the X chromosome.
UniProt Protein Function:CTNNBL1: Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. Participates in AID/AICDA-mediated Ig class switching recombination (CSR). May induce apoptosis. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:RNA splicing; Spliceosome

Chromosomal Location of Human Ortholog: 20q11.23-q12

Cellular Component: nucleoplasm; spliceosome; membrane; cytoplasm; nucleus

Molecular Function:protein binding; enzyme binding

Biological Process: nuclear mRNA splicing, via spliceosome; somatic diversification of immunoglobulins; positive regulation of apoptosis; apoptosis; RNA splicing; gene expression

NCBI Summary:The protein encoded by this gene is a component of the pre-mRNA-processing factor 19-cell division cycle 5-like (PRP19-CDC5L) protein complex, which activates pre-mRNA splicing and is an integral part of the spliceosome. The encoded protein is also a nuclear localization sequence binding protein, and binds to activation-induced deaminase and is important for antibody diversification. This gene may also be associated with the development of obesity. Alternative splicing results in multiple transcript variants. A pseudogene of this gene has been defined on the X chromosome. [provided by RefSeq, Jul 2013]
UniProt Code:Q8WYA6
NCBI GenInfo Identifier:29840792
NCBI Gene ID:56259
NCBI Accession:Q8WYA6.1
UniProt Related Accession:Q8WYA6
Molecular Weight:65.2kDa
NCBI Full Name:Beta-catenin-like protein 1
NCBI Synonym Full Names:catenin beta like 1
NCBI Official Symbol:CTNNBL1  
NCBI Official Synonym Symbols:NAP; P14L; PP8304; C20orf33; dJ633O20.1  
NCBI Protein Information:beta-catenin-like protein 1
UniProt Protein Name:Beta-catenin-like protein 1
UniProt Synonym Protein Names:Nuclear-associated protein; NAP; Testis development protein NYD-SP19
Protein Family:Beta-catenin-like protein
UniProt Gene Name:CTNNBL1  
UniProt Entry Name:CTBL1_HUMAN
Anti-CTNNBL1 Antibody (CAB6572)Western blot analysis of extracts of various cell lines, using CTNNBL1 Antibody (CAB6572) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
Anti-CTNNBL1 Antibody (CAB6572)Immunofluorescence analysis of U2OS cells using CTNNBL1 antibody (CAB6572). Blue: DAPI for nuclear staining.
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