ChIP Antibodies
Anti-CTNNBIP1 Antibody (CAB7122)
- SKU:
- CAB7122
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Metabolism
Description
| Antibody Name: | Anti-CTNNBIP1 Antibody |
| Antibody SKU: | CAB7122 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-81 of human CTNNBIP1 (NP_064633.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse |
| Positive Samples: | Mouse heart |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-81 of human CTNNBIP1 (NP_064633.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MNRE GAPG KSPE EMYI QQKV RVLL MLRK MGSN LTAS EEEF LRTY AGVV NSQL SQLP PHSI DQGA EDVV MAFS RSET EDRR Q |
| Gene ID: | 56998 |
| Uniprot: | Q9NSA3 |
| Cellular Location: | Cytoplasm, Nucleus |
| Calculated MW: | 9kDa |
| Observed MW: | 15kDa |
| Synonyms: | CTNNBIP1, ICAT |
| Background: | The protein encoded by this gene binds CTNNB1 and prevents interaction between CTNNB1 and TCF family members. The encoded protein is a negative regulator of the Wnt signaling pathway. Two transcript variants encoding the same protein have been found for this gene. |
| UniProt Protein Function: | CTNNBIP1: Prevents the interaction between CTNNB1 and TCF family members, and acts as negative regulator of the Wnt signaling pathway. Belongs to the CTNNBIP1 family. |
| UniProt Protein Details: | Protein type:Cell development/differentiation; Inhibitor Chromosomal Location of Human Ortholog: 1p36.22 Cellular Component: nucleoplasm; cytoplasm; nucleus; beta-catenin destruction complex; cytosol Molecular Function:protein binding; beta-catenin binding Biological Process: anterior/posterior pattern formation; positive regulation of monocyte differentiation; positive regulation of osteoblast differentiation; Wnt receptor signaling pathway; negative regulation of Wnt receptor signaling pathway; ureteric bud branching; negative regulation of smooth muscle cell proliferation; negative regulation of transcription factor activity; negative regulation of protein binding; regulation of vascular permeability during acute inflammatory response; negative regulation of DNA binding |
| NCBI Summary: | The protein encoded by this gene binds CTNNB1 and prevents interaction between CTNNB1 and TCF family members. The encoded protein is a negative regulator of the Wnt signaling pathway. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9NSA3 |
| NCBI GenInfo Identifier: | 59889555 |
| NCBI Gene ID: | 56998 |
| NCBI Accession: | NP_001012329.1 |
| UniProt Secondary Accession: | Q9NSA3,Q9JJN6, |
| UniProt Related Accession: | Q9NSA3 |
| Molecular Weight: | 9,170 Da |
| NCBI Full Name: | beta-catenin-interacting protein 1 |
| NCBI Synonym Full Names: | catenin, beta interacting protein 1 |
| NCBI Official Symbol: | CTNNBIP1 |
| NCBI Official Synonym Symbols: | ICAT |
| NCBI Protein Information: | beta-catenin-interacting protein 1; beta-catenin-interacting protein ICAT; inhibitor of beta-catenin and Tcf-4 |
| UniProt Protein Name: | Beta-catenin-interacting protein 1 |
| UniProt Synonym Protein Names: | Inhibitor of beta-catenin and Tcf-4 |
| UniProt Gene Name: | CTNNBIP1 |
| UniProt Entry Name: | CNBP1_HUMAN |
 | Western blot analysis of extracts of mouse heart, using CTNNBIP1 antibody (CAB7122) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 30s. |
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