Cell Biology Antibodies 2
Anti-CTGF Antibody (CAB11456)
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- SKU:
- CAB11456
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-CTGF Antibody |
| Antibody SKU: | CAB11456 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 27-349 of human CTGF (NP_001892.1). |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | SW480, Mouse kidney |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 27-349 of human CTGF (NP_001892.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | QNCS GPCR CPDE PAPR CPAG VSLV LDGC GCCR VCAK QLGE LCTE RDPC DPHK GLFC DFGS PANR KIGV CTAK DGAP CIFG GTVY RSGE SFQS SCKY QCTC LDGA VGCM PLCS MDVR LPSP DCPF PRRV KLPG KCCE EWVC DEPK DQTV VGPA LAAY RLED TFGP DPTM IRAN CLVQ TTEW SACS KTCG MGIS TRVT NDNA SCRL EKQS RLCM VRPC EADL EENI KKGK KCIR TPKI SKPI KFEL SGCT SMKT YRAK FCGV CTDG RCCT PHRT TTLP VEFK CPDG EVMK KNMM FIKT CACH YNCP GDND IFES LYYR KMYG DMA |
| Gene ID: | 1490 |
| Uniprot: | P29279 |
| Cellular Location: | Secreted, extracellular matrix, extracellular space |
| Calculated MW: | 35kDa/38kDa |
| Observed MW: | 35kDa |
| Synonyms: | CTGF, CCN2, HCS24, IGFBP8, NOV2 |
| Background: | The protein encoded by this gene is a mitogen that is secreted by vascular endothelial cells. The encoded protein plays a role in chondrocyte proliferation and differentiation, cell adhesion in many cell types, and is related to platelet-derived growth factor. Certain polymorphisms in this gene have been linked with a higher incidence of systemic sclerosis. |
| UniProt Protein Function: | CTGF: Major connective tissue mitoattractant secreted by vascular endothelial cells. Promotes proliferation and differentiation of chondrocytes. Mediates heparin- and divalent cation-dependent cell adhesion in many cell types including fibroblasts, myofibroblasts, endothelial and epithelial cells. Enhances fibroblast growth factor-induced DNA synthesis. Belongs to the CCN family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Cell adhesion; Secreted; Secreted, signal peptide Chromosomal Location of Human Ortholog: 6q23.2 Cellular Component: extracellular region; Golgi apparatus; intracellular membrane-bound organelle; plasma membrane Molecular Function:protein binding; protein C-terminus binding Biological Process: epidermis development; positive regulation of cell differentiation; positive regulation of JNK cascade; positive regulation of stress fiber formation; response to wounding; transcription initiation from RNA polymerase II promoter |
| NCBI Summary: | The protein encoded by this gene is a mitogen that is secreted by vascular endothelial cells. The encoded protein plays a role in chondrocyte proliferation and differentiation, cell adhesion in many cell types, and is related to platelet-derived growth factor. Certain polymorphisms in this gene have been linked with a higher incidence of systemic sclerosis. [provided by RefSeq, Nov 2009] |
| UniProt Code: | P29279 |
| NCBI GenInfo Identifier: | 116241320 |
| NCBI Gene ID: | 1490 |
| NCBI Accession: | P29279.2 |
| UniProt Secondary Accession: | P29279,Q6LCY0, Q96A79, Q96QX2, Q9UDL6, E1P578, |
| UniProt Related Accession: | P29279 |
| Molecular Weight: | 38kDa |
| NCBI Full Name: | Connective tissue growth factor |
| NCBI Synonym Full Names: | connective tissue growth factor |
| NCBI Official Symbol: | CTGF |
| NCBI Official Synonym Symbols: | CCN2; NOV2; HCS24; IGFBP8 |
| NCBI Protein Information: | connective tissue growth factor |
| UniProt Protein Name: | Connective tissue growth factor |
| UniProt Synonym Protein Names: | CCN family member 2; Hypertrophic chondrocyte-specific protein 24; Insulin-like growth factor-binding protein 8; IBP-8; IGF-binding protein 8; IGFBP-8 |
| Protein Family: | Connective tissue growth factor |
| UniProt Gene Name: | CTGF |
 | Western blot analysis of extracts of various cell lines, using CTGF antibody (CAB11456) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 60s. |
 | Immunohistochemistry of paraffin-embedded Mouse spinal cord using CTGF Rabbit pAb (CAB11456) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded Rat kidney using CTGF Rabbit pAb (CAB11456) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded Human colon using CTGF Rabbit pAb (CAB11456) at dilution of 1:100 (40x lens). |
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