Cell Biology Antibodies 14
Anti-CTDSP1 Antibody (CAB18184)
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- SKU:
- CAB18184
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-CTDSP1 Antibody |
| Antibody SKU: | CAB18184 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant protein of human CTDSP1 . |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Mouse, Rat |
| Positive Samples: | Mouse brain, Rat liver |
| Immunogen: | Recombinant protein of human CTDSP1 . |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 58190 |
| Uniprot: | Q9GZU7 |
| Cellular Location: | |
| Calculated MW: | 29kDa |
| Observed MW: | 29kDa |
 | Western blot - CTDSP1 Polyclonal Antibody (CAB18184) |
| Synonyms: | NIF3, SCP1, NLIIF, NLI-IF, CTDSP1 |
| Background: | This gene encodes a member of the small C-terminal domain phosphatase (SCP) family of nuclear phosphatases. These proteins play a role in transcriptional regulation through specific dephosphorylation of phosphoserine 5 within tandem heptapeptide repeats of the C-terminal domain of RNA polymerase II. The encoded protein plays a role in neuronal gene silencing in non-neuronal cells, and may also inhibit osteoblast differentiation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. |
| UniProt Protein Function: | CTDSP1: Preferentially catalyzes the dephosphorylation of 'Ser- 5' within the tandem 7 residues repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation. Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:EC 3.1.3.16; Protein phosphatase, Ser/Thr (non-receptor) Chromosomal Location of Human Ortholog: 2q35 Cellular Component: nucleus Molecular Function:protein binding; metal ion binding; CTD phosphatase activity Biological Process: regulation of transcription from RNA polymerase II promoter; negative regulation of neuron differentiation; negative regulation of protein amino acid phosphorylation; protein amino acid dephosphorylation |
| NCBI Summary: | This gene encodes a member of the small C-terminal domain phosphatase (SCP) family of nuclear phosphatases. These proteins play a role in transcriptional regulation through specific dephosphorylation of phosphoserine 5 within tandem heptapeptide repeats of the C-terminal domain of RNA polymerase II. The encoded protein plays a role in neuronal gene silencing in non-neuronal cells, and may also inhibit osteoblast differentiation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2011] |
| UniProt Code: | Q9GZU7 |
| NCBI GenInfo Identifier: | 17865510 |
| NCBI Gene ID: | 58190 |
| NCBI Accession: | Q9GZU7.1 |
| UniProt Secondary Accession: | Q9GZU7,Q7Z5Q3, Q7Z5Q4, C9IYG0, |
| UniProt Related Accession: | Q9GZU7 |
| Molecular Weight: | 29,128 Da |
| NCBI Full Name: | Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 |
| NCBI Synonym Full Names: | CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1 |
| NCBI Official Symbol: | CTDSP1 |
| NCBI Official Synonym Symbols: | NIF3; SCP1; NLIIF; NLI-IF |
| NCBI Protein Information: | carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1; NLI-interacting factor 3; small C-terminal domain phosphatase 1; nuclear LIM interactor-interacting factor 3 |
| UniProt Protein Name: | Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 |
| UniProt Synonym Protein Names: | Nuclear LIM interactor-interacting factor 3; NLI-IF; NLI-interacting factor 3; Small C-terminal domain phosphatase 1; SCP1; Small CTD phosphatase 1 |
| Protein Family: | Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase |
| UniProt Gene Name: | CTDSP1 |
| UniProt Entry Name: | CTDS1_HUMAN |
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