Epigenetics & Nuclear Signaling Antibodies 4
Anti-CSTF2 Antibody (CAB8116)
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- SKU:
- CAB8116
- Product Type:
- Antibody
- Applications:
- WB
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Epigenetics and Nuclear Signaling
Description
| Antibody Name: | CSTF2 Rabbit Polyclonal Antibody |
| Antibody SKU: | CAB8116 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-180 of human CSTF2 (NP_001316.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HeLa, Jurkat, HepG2, SW620, Mouse testis, Mouse thymus |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-180 of human CSTF2 (NP_001316.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MAGL TVRD PAVD RSLR SVFV GNIP YEAT EEQL KDIF SEVG PVVS FRLV YDRE TGKP KGYG FCEY QDQE TALS AMRN LNGR EFSG RALR VDNA ASEK NKEE LKSL GTGA PVIE SPYG ETIS PEDA PESI SKAV ASLP PEQM FELM KQMK LCVQ NSPQ EARN MLLQ NPQL AYAL LQAQ VVMR |
| Gene ID: | 1478 |
| Uniprot: | P33240 |
| Cellular Location: | Nucleus |
| Calculated MW: | 59kDa/60kDa |
| Observed MW: | 61kDa |
| Synonyms: | CSTF2, CstF-64 |
| Background: | This gene encodes a nuclear protein with an RRM (RNA recognition motif) domain. The protein is a member of the cleavage stimulation factor (CSTF) complex that is involved in the 3' end cleavage and polyadenylation of pre-mRNAs. Specifically, this protein binds GU-rich elements within the 3'-untranslated region of mRNAs. |
| UniProt Protein Function: | CSTF2: One of the multiple factors required for polyadenylation and 3'-end cleavage of mammalian pre-mRNAs. This subunit is directly involved in the binding to pre-mRNAs. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:RNA splicing; RNA-binding Chromosomal Location of Human Ortholog: Xq22.1 Cellular Component: mRNA cleavage and polyadenylation specificity factor complex; nucleoplasm; nucleus Molecular Function:mRNA binding; protein binding; RNA binding Biological Process: mRNA 3'-end processing; mRNA cleavage; nuclear mRNA splicing, via spliceosome; termination of RNA polymerase II transcription; tRNA splicing |
| NCBI Summary: | This gene encodes a nuclear protein with an RRM (RNA recognition motif) domain. The protein is a member of the cleavage stimulation factor (CSTF) complex that is involved in the 3' end cleavage and polyadenylation of pre-mRNAs. Specifically, this protein binds GU-rich elements within the 3'-untranslated region of mRNAs. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P33240 |
| NCBI GenInfo Identifier: | 461847 |
| NCBI Gene ID: | 1478 |
| NCBI Accession: | P33240.1 |
| UniProt Secondary Accession: | P33240,Q5H951, Q6LA74, Q8N502, |
| UniProt Related Accession: | P33240 |
| Molecular Weight: | 59,251 Da |
| NCBI Full Name: | Cleavage stimulation factor subunit 2 |
| NCBI Synonym Full Names: | cleavage stimulation factor subunit 2 |
| NCBI Official Symbol: | CSTF2 |
| NCBI Official Synonym Symbols: | CstF-64 |
| NCBI Protein Information: | cleavage stimulation factor subunit 2 |
| UniProt Protein Name: | Cleavage stimulation factor subunit 2 |
| UniProt Synonym Protein Names: | CF-1 64 kDa subunit; Cleavage stimulation factor 64 kDa subunit; CSTF 64 kDa subunit; CstF-64 |
| Protein Family: | Cleavage stimulation factor |
| UniProt Gene Name: | CSTF2 |
| UniProt Entry Name: | CSTF2_HUMAN |
 | Western blot analysis of extracts of various cell lines, using CSTF2 antibody (CAB8116) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 20s. |
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