Cell Biology Antibodies 10

Anti-CST2 Antibody (CAB6571)

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SKU:
CAB6571
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-CST2 Antibody
Antibody SKU:CAB6571
Antibody Size:20uL, 50uL, 100uL
Application:WB IF
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 20-141 of human CST2 (NP_001313.1).
Application:WB IF
Recommended Dilution:WB 1:500 - 1:2000 IF 1:50 - 1:100
Reactivity:Human, Mouse
Positive Samples:Mouse heart
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 20-141 of human CST2 (NP_001313.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:AWSP QEED RIIE GGIY DADL NDER VQRA LHFV ISEY NKAT EDEY YRRL LRVL RARE QIVG GVNY FFDI EVGR TICT KSQP NLDT CAFH EQPE LQKK QLCS FQIY EVPW EDRM SLVN SRCQ EA
Gene ID:1470
Uniprot:P09228
Cellular Location:Secreted
Calculated MW:16kDa
Observed MW:14kDa
Synonyms:CST2
Background:The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions, where they appear to provide protective functions. The cystatin locus on chromosome 20 contains the majority of the type 2 cystatin genes and pseudogenes. This gene is located in the cystatin locus and encodes a secreted thiol protease inhibitor found at high levels in saliva, tears and seminal plasma.
UniProt Protein Function:CST2: Thiol protease inhibitor. Belongs to the cystatin family.
UniProt Protein Details:

Protein type:Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 20p11.21

Cellular Component: extracellular space

Molecular Function:cysteine protease inhibitor activity

Biological Process: detection of chemical stimulus involved in sensory perception of bitter taste

NCBI Summary:The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions, where they appear to provide protective functions. The cystatin locus on chromosome 20 contains the majority of the type 2 cystatin genes and pseudogenes. This gene is located in the cystatin locus and encodes a secreted thiol protease inhibitor found at high levels in saliva, tears and seminal plasma. [provided by RefSeq, Jul 2008]
UniProt Code:P09228
NCBI GenInfo Identifier:118192
NCBI Gene ID:1470
NCBI Accession:P09228.1
UniProt Secondary Accession:P09228,Q9UCQ7,
UniProt Related Accession:P09228
Molecular Weight:141
NCBI Full Name:Cystatin-SA
NCBI Synonym Full Names:cystatin SA
NCBI Official Symbol:CST2  
NCBI Protein Information:cystatin-SA; cystatin 2; cystatin-2; cystatin S5; cystatin-S5; cysteine-proteinase inhibitor; salivary cysteine (thiol) protease inhibitor
UniProt Protein Name:Cystatin-SA
UniProt Synonym Protein Names:Cystatin-2; Cystatin-S5
Protein Family:Cystatin
UniProt Gene Name:CST2  
UniProt Entry Name:CYTT_HUMAN
Anti-CST2 Antibody (CAB6571)Western blot analysis of extracts of mouse heart, using CST2 antibody (CAB6571) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 5min.
Anti-CST2 Antibody (CAB6571)Immunofluorescence analysis of HeLa cells using CST2 antibody (CAB6571). Blue: DAPI for nuclear staining.
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