Signal Transduction Antibodies 1

Anti-CSH1 Antibody (CAB14528)

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SKU:
CAB14528
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Signal Transduction

Description

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Antibody Name:Anti-CSH1 Antibody
Antibody SKU:CAB14528
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 27-207 of human CSH1 (NP_001308.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human
Positive Samples:HeLa, U-87MG
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 27-207 of human CSH1 (NP_001308.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:VQTV PLSR LFDH AMLQ AHRA HQLA IDTY QEFE ETYI PKDQ KYSF LHDS QTSF CFSD SIPT PSNM EETQ QKSN LELL RISL LLIE SWLE PVRF LRSM FANN LVYD TSDS DDYH LLKD LEEG IQTL MGRL EDGS RRTG QILK QTYS KFDT NSHN HDAL LKNY GLLY CFRK DMDK VETF LRMV Q
Gene ID:1442
Uniprot:P0DML2
Cellular Location:
Calculated MW:25kDa
Observed MW:23kDa
Synonyms:CSH1, CS-1, CSA, CSMT, GHB3, PL, hCS-1, hCS-A
Background:The protein encoded by this gene is a member of the somatotropin/prolactin family of hormones and plays an important role in growth control. The gene is located at the growth hormone locus on chromosome 17 along with four other related genes in the same transcriptional orientation; an arrangement which is thought to have evolved by a series of gene duplications. Although the five genes share a remarkably high degree of sequence identity, they are expressed selectively in different tissues. Alternative splicing generates additional isoforms of each of the five growth hormones, leading to further diversity and potential for specialization. This particular family member is expressed mainly in the placenta and utilizes multiple transcription initiation sites. Expression of the identical mature proteins for chorionic somatomammotropin hormones 1 and 2 is upregulated during development, although the ratio of 1 to 2 increases by term. Mutations in this gene result in placental lactogen deficiency and Silver-Russell syndrome.
UniProt Protein Function:CSH1: Produced only during pregnancy and is involved in stimulating lactation, fetal growth and metabolism. Does not interact with GHR but only activates PRLR through zinc-induced dimerization. Belongs to the somatotropin/prolactin family.
UniProt Protein Details:

Protein type:Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 17q24.2

Cellular Component: extracellular region

Molecular Function:hormone activity; metal ion binding

NCBI Summary:The protein encoded by this gene is a member of the somatotropin/prolactin family of hormones and plays an important role in growth control. The gene is located at the growth hormone locus on chromosome 17 along with four other related genes in the same transcriptional orientation; an arrangement which is thought to have evolved by a series of gene duplications. Although the five genes share a remarkably high degree of sequence identity, they are expressed selectively in different tissues. Alternative splicing generates additional isoforms of each of the five growth hormones, leading to further diversity and potential for specialization. This particular family member is expressed mainly in the placenta and utilizes multiple transcription initiation sites. Expression of the identical mature proteins for chorionic somatomammotropin hormones 1 and 2 is upregulated during development, although the ratio of 1 to 2 increases by term. Mutations in this gene result in placental lactogen deficiency and Silver-Russell syndrome. [provided by RefSeq, Jul 2008]
UniProt Code:P0DML2
NCBI GenInfo Identifier:190034
NCBI Gene ID:1442
NCBI Accession:AAA98621.1
UniProt Secondary Accession:P0DML2,P01243, Q0VDB1, Q14407,
UniProt Related Accession:P0DML2
Molecular Weight:25,020 Da
NCBI Full Name:placental lactogen
NCBI Synonym Full Names:chorionic somatomammotropin hormone 1 (placental lactogen)
NCBI Official Symbol:CSH1  
NCBI Official Synonym Symbols:PL; CSA; CS-1; CSMT; hCS-1; hCS-A  
NCBI Protein Information:chorionic somatomammotropin hormone 1; choriomammotropin; placental lactogen; chorionic somatomammotropin A; chorionic somatomammotropin-1
UniProt Protein Name:Chorionic somatomammotropin hormone 1
UniProt Synonym Protein Names:Lactogen; Placental lactogen; PL
UniProt Gene Name:CSH1  
UniProt Entry Name:CSH1_HUMAN
Anti-CSH1 Antibody (CAB14528)Western blot analysis of extracts of various cell lines, using CSH1 antibody (CAB14528) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
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