Cell Biology Antibodies 11
Anti-CSF3R Antibody (CAB7661)
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- SKU:
- CAB7661
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-CSF3R Antibody |
| Antibody SKU: | CAB7661 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 650-750 of human CSF3R (NP_000751.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: | U-937, 293T |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 650-750 of human CSF3R (NP_000751.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | CSPN RKNP LWPS VPDP AHSS LGSW VPTI MEED AFQL PGLG TPPI TKLT VLEE DEKK PVPW ESHN SSET CGLP TLVQ TYVL QGDP RAVS TQPQ SQSG TSDQ V |
| Gene ID: | 1441 |
| Uniprot: | Q99062 |
| Cellular Location: | Cell membrane, Secreted, Single-pass type I membrane protein |
| Calculated MW: | 85kDa/86kDa/92kDa/95kDa |
| Observed MW: | 102kDa |
| Synonyms: | CSF3R, CD114, GCSFR, SCN7 |
| Background: | The protein encoded by this gene is the receptor for colony stimulating factor 3, a cytokine that controls the production, differentiation, and function of granulocytes. The encoded protein, which is a member of the family of cytokine receptors, may also function in some cell surface adhesion or recognition processes. Alternatively spliced transcript variants have been described. Mutations in this gene are a cause of Kostmann syndrome, also known as severe congenital neutropenia. |
| UniProt Protein Function: | GCSFR: the receptor for colony stimulating factor 3, a cytokine that controls the production, differentiation, and function of granulocytes. The encoded protein, which is a member of the family of cytokine receptors, may also function in some cell surface adhesion or recognition processes. Four transcript variant isoforms have been described. |
| UniProt Protein Details: | Protein type:Receptor, cytokine; Membrane protein, integral Chromosomal Location of Human Ortholog: 1p35-p34.3 Cellular Component: integral to plasma membrane; extracellular region Molecular Function:hematopoietin/interferon-class (D200-domain) cytokine receptor activity; protein binding; receptor activity Biological Process: neutrophil chemotaxis; cytokine and chemokine mediated signaling pathway; defense response; cell adhesion; signal transduction Disease: Neutrophilia, Hereditary |
| NCBI Summary: | The protein encoded by this gene is the receptor for colony stimulating factor 3, a cytokine that controls the production, differentiation, and function of granulocytes. The encoded protein, which is a member of the family of cytokine receptors, may also function in some cell surface adhesion or recognition processes. Alternatively spliced transcript variants have been described. Mutations in this gene are a cause of Kostmann syndrome, also known as severe congenital neutropenia. [provided by RefSeq, Aug 2010] |
| UniProt Code: | Q99062 |
| NCBI GenInfo Identifier: | 729564 |
| NCBI Gene ID: | 1441 |
| NCBI Accession: | Q99062.1 |
| UniProt Related Accession: | Q99062 |
| Molecular Weight: | |
| NCBI Full Name: | Granulocyte colony-stimulating factor receptor |
| NCBI Synonym Full Names: | colony stimulating factor 3 receptor (granulocyte) |
| NCBI Official Symbol: | CSF3R |
| NCBI Official Synonym Symbols: | CD114; GCSFR |
| NCBI Protein Information: | granulocyte colony-stimulating factor receptor; G-CSF-R; CD114 antigen; G-CSF receptor |
| UniProt Protein Name: | Granulocyte colony-stimulating factor receptor |
| UniProt Synonym Protein Names: | CD_antigen: CD114 |
| Protein Family: | Granulocyte colony-stimulating factor receptor |
| UniProt Gene Name: | CSF3R |
| UniProt Entry Name: | CSF3R_HUMAN |
 | Western blot analysis of extracts of various cell lines, using CSF3R antibody (CAB7661) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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