Cell Biology Antibodies 10
Anti-CSF3 Antibody (CAB6178)
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- SKU:
- CAB6178
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-CSF3 Antibody |
| Antibody SKU: | CAB6178 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 30-207 of human CSF3 (NP_000750.1). |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:1000 IHC 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HL-60, 293T, Mouse liver |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 30-207 of human CSF3 (NP_000750.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | ATPL GPAS SLPQ SFLL KCLE QVRK IQGD GAAL QEKL VSEC ATYK LCHP EELV LLGH SLGI PWAP LSSC PSQA LQLA GCLS QLHS GLFL YQGL LQAL EGIS PELG PTLD TLQL DVAD FATT IWQQ MEEL GMAP ALQP TQGA MPAF ASAF QRRA GGVL VASH LQSF LEVS YRVL RHLA QP |
| Gene ID: | 1440 |
| Uniprot: | P09919 |
| Cellular Location: | Secreted |
| Calculated MW: | 18kDa/21kDa/22kDa |
| Observed MW: | 22kDa |
| Synonyms: | CSF3, C17orf33, CSF3OS, GCSF |
| Background: | The protein encoded by this gene is a cytokine that controls the production, differentiation, and function of granulocytes. The active protein is found extracellularly. Alternatively spliced transcript variants have been described for this gene. |
| UniProt Protein Function: | G-CSF: Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. This CSF induces granulocytes. Belongs to the IL-6 superfamily. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Cytokine; Secreted, signal peptide; Cell cycle regulation; Secreted Chromosomal Location of Human Ortholog: 17q11.2-q12 Cellular Component: extracellular space Molecular Function:enzyme binding; growth factor activity; cytokine activity; granulocyte colony-stimulating factor receptor binding Biological Process: positive regulation of protein binding; positive regulation of myeloid cell differentiation; granulocyte differentiation; multicellular organismal development; cytokine and chemokine mediated signaling pathway; positive regulation of peptidyl-serine phosphorylation; positive regulation of phosphoinositide 3-kinase cascade; positive regulation of protein kinase B signaling cascade; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of actin filament polymerization; positive regulation of cell proliferation; positive regulation of transcription factor import into nucleus; immune response; positive regulation of transcription from RNA polymerase II promoter |
| NCBI Summary: | The protein encoded by this gene is a cytokine that controls the production, differentiation, and function of granulocytes. The active protein is found extracellularly. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, May 2010] |
| UniProt Code: | P09919 |
| NCBI GenInfo Identifier: | 117564 |
| NCBI Gene ID: | 1440 |
| NCBI Accession: | P09919.1 |
| UniProt Secondary Accession: | P09919,A8MXR7, |
| UniProt Related Accession: | P09919 |
| Molecular Weight: | 18,434 Da |
| NCBI Full Name: | Granulocyte colony-stimulating factor |
| NCBI Synonym Full Names: | colony stimulating factor 3 (granulocyte) |
| NCBI Official Symbol: | CSF3 |
| NCBI Official Synonym Symbols: | GCSF; CSF3OS; C17orf33 |
| NCBI Protein Information: | granulocyte colony-stimulating factor; filgrastim; lenograstim; pluripoietin |
| UniProt Protein Name: | Granulocyte colony-stimulating factor |
| UniProt Synonym Protein Names: | Pluripoietin; INN: Filgrastim; INN: Lenograstim |
| Protein Family: | Granulocyte colony-stimulating factor |
| UniProt Gene Name: | CSF3 |
| UniProt Entry Name: | CSF3_HUMAN |
 | Western blot analysis of extracts of various cell lines, using CSF3 antibody (CAB6178) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 90s. |
 | Immunohistochemistry of paraffin-embedded rat spleen using CSF3 antibody (CAB6178) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded human colon using CSF3 antibody (CAB6178) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded mouse spleen using CSF3 antibody (CAB6178) at dilution of 1:100 (40x lens). |
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