Cell Biology Antibodies 2

Anti-CSF2RB Antibody (CAB10501)

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SKU:
CAB10501
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-CSF2RB Antibody
Antibody SKU:CAB10501
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 200-443 of human CSF2RB (NP_000386.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:LO2, Mouse spleen, Mouse liver, Mouse lung, Mouse thymus, Rat liver
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 200-443 of human CSF2RB (NP_000386.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:EHLM PSST YVAR VRTR LAPG SRLS GRPS KWSP EVCW DSQP GDEA QPQN LECF FDGA AVLS CSWE VRKE VASS VSFG LFYK PSPD AGEE ECSP VLRE GLGS LHTR HHCQ IPVP DPAT HGQY IVSV QPRR AEKH IKSS VNIQ MAPP SLNV TKDG DSYS LRWE TMKM RYEH IDHT FEIQ YRKD TATW KDSK TETL QNAH SMAL PALE PSTR YWAR VRVR TSRT GYNG IWSE WSEA RSWD TESV LPMW
Gene ID:1439
Uniprot:P32927
Cellular Location:Membrane, Single-pass type I membrane protein
Calculated MW:97kDa
Observed MW:130kDa
Synonyms:CSF2RB, CD131, CDw131, IL3RB, IL5RB, SMDP5
Background:The protein encoded by this gene is the common beta chain of the high affinity receptor for IL-3, IL-5 and CSF. Defects in this gene have been reported to be associated with protein alveolar proteinosis (PAP).
UniProt Protein Function:CSF2RB: a common beta chain of the high affinity receptor for IL-3, IL-5 and CSF. A type I cytokine family of receptor. Defects are a cause of congenital pulmonary alveolar proteinosis (PAP) [MIM:265120]. PAP is an autosomal recessive fatal respiratory disease.
UniProt Protein Details:

Protein type:Membrane protein, integral; Receptor, cytokine

Chromosomal Location of Human Ortholog: 22q13.1

Cellular Component: granulocyte macrophage colony-stimulating factor receptor complex; plasma membrane

Molecular Function:interleukin-3 receptor activity; interleukin-5 receptor activity; protein binding; protein-tyrosine kinase activity; Ras guanyl-nucleotide exchange factor activity; receptor activity

Biological Process: cellular protein metabolic process; MAPKKK cascade; respiratory gaseous exchange

Disease: Surfactant Metabolism Dysfunction, Pulmonary, 5

NCBI Summary:The protein encoded by this gene is the common beta chain of the high affinity receptor for IL-3, IL-5 and CSF. Defects in this gene have been reported to be associated with protein alveolar proteinosis (PAP). [provided by RefSeq, Jul 2008]
UniProt Code:P32927
NCBI GenInfo Identifier:1345923
NCBI Gene ID:1439
NCBI Accession:P32927.2
UniProt Secondary Accession:P32927,Q5JZI1, Q6ICE0,
UniProt Related Accession:P32927
Molecular Weight:97,976 Da
NCBI Full Name:Cytokine receptor common subunit beta
NCBI Synonym Full Names:colony stimulating factor 2 receptor beta common subunit
NCBI Official Symbol:CSF2RB  
NCBI Official Synonym Symbols:CD131; IL3RB; IL5RB; SMDP5; CDw131  
NCBI Protein Information:cytokine receptor common subunit beta
UniProt Protein Name:Cytokine receptor common subunit beta
UniProt Synonym Protein Names:CDw131; GM-CSF/IL-3/IL-5 receptor common beta subunit; CD_antigen: CD131
Protein Family:Cytokine receptor
UniProt Gene Name:CSF2RB  
UniProt Entry Name:IL3RB_HUMAN
Anti-CSF2RB Antibody (CAB10501)Western blot analysis of extracts of various cell lines, using CSF2RB antibody (CAB10501) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s.
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