Cell Biology Antibodies 3

Anti-CSF2RA Antibody (CAB13181)

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SKU:
CAB13181
Product Type:
Antibody
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-CSF2RA Antibody
Antibody SKU:CAB13181
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 23-150 of human CSF2RA (NP_001155001.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Mouse, Rat
Positive Samples:Mouse liver, Mouse brain, Rat brain, Rat liver
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 23-150 of human CSF2RA (NP_001155001.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:EKSD LRTV APAS SLNV RFDS RTMN LSWD CQEN TTFS KCFL TDKK NRVV EPRL SNNE CSCT FREI CLHE GVTF EVHV NTSQ RGFQ QKLL YPNS GREG TAAQ NFSC FIYN ADLM NCTW ARGP TAPR DVQY
Gene ID:1438
Uniprot:P15509
Cellular Location:Cell membrane, Secreted, Single-pass type I membrane protein
Calculated MW:26kDa/31kDa/32kDa/38kDa/43kDa/46kDa/49kDa
Observed MW:48kDa
Synonyms:CSF2RA, CD116, CDw116, CSF2R, CSF2RAX, CSF2RAY, CSF2RX, CSF2RY, GM-CSF-R-alpha, GMCSFR, GMR, SMDP4
Background:The protein encoded by this gene is the alpha subunit of the heterodimeric receptor for colony stimulating factor 2, a cytokine which controls the production, differentiation, and function of granulocytes and macrophages. The encoded protein is a member of the cytokine family of receptors. This gene is found in the pseudoautosomal region (PAR) of the X and Y chromosomes. Multiple transcript variants encoding different isoforms have been found for this gene, with some of the isoforms being membrane-bound and others being soluble.
UniProt Protein Function:CSF2RA: Low affinity receptor for granulocyte-macrophage colony- stimulating factor. Transduces a signal that results in the proliferation, differentiation, and functional activation of hematopoietic cells. Defects in CSF2RA are the cause of pulmonary surfactant metabolism dysfunction type 4 (SMDP4). A rare lung disorder due to impaired surfactant homeostasis. It is characterized by alveolar filling with floccular material that stains positive using the periodic acid-Schiff method and is derived from surfactant phospholipids and protein components. Excessive lipoproteins accumulation in the alveoli results in severe respiratory distress. Belongs to the type I cytokine receptor family. Type 5 subfamily. 8 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Membrane protein, integral; Receptor, cytokine

Chromosomal Location of Human Ortholog: Xp22.32 and Yp11.3

Cellular Component: extracellular region; integral to plasma membrane; intracellular; plasma membrane

Molecular Function:granulocyte colony-stimulating factor binding; granulocyte colony-stimulating factor receptor activity; protein binding; receptor activity

Biological Process: activation of MAPKK activity; axon guidance; cellular protein metabolic process; epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; innate immune response; insulin receptor signaling pathway; MAPKKK cascade; nerve growth factor receptor signaling pathway; Ras protein signal transduction; small GTPase mediated signal transduction; vascular endothelial growth factor receptor signaling pathway

Disease: Surfactant Metabolism Dysfunction, Pulmonary, 4

NCBI Summary:The protein encoded by this gene is the alpha subunit of the heterodimeric receptor for colony stimulating factor 2, a cytokine which controls the production, differentiation, and function of granulocytes and macrophages. The encoded protein is a member of the cytokine family of receptors. This gene is found in the pseudoautosomal region (PAR) of the X and Y chromosomes. Multiple transcript variants encoding different isoforms have been found for this gene, with some of the isoforms being membrane-bound and others being soluble. [provided by RefSeq, Jul 2008]
UniProt Code:P15509
NCBI GenInfo Identifier:121509
NCBI Gene ID:1438
NCBI Accession:P15509.1
UniProt Secondary Accession:P15509,O00207, Q14429, Q14430, Q14431, Q16564, A7J003 A8KAM1, B4DW68, J3JS76, J3JS77,
UniProt Related Accession:P15509
Molecular Weight:31,101 Da
NCBI Full Name:Granulocyte-macrophage colony-stimulating factor receptor subunit alpha
NCBI Synonym Full Names:colony stimulating factor 2 receptor alpha subunit
NCBI Official Symbol:CSF2RA  
NCBI Official Synonym Symbols:GMR; CD116; CSF2R; SMDP4; CDw116; CSF2RX; CSF2RY; GMCSFR; CSF2RAX; CSF2RAY; GM-CSF-R-alpha  
NCBI Protein Information:granulocyte-macrophage colony-stimulating factor receptor subunit alpha
UniProt Protein Name:Granulocyte-macrophage colony-stimulating factor receptor subunit alpha
UniProt Synonym Protein Names:CDw116; CD_antigen: CD116
Protein Family:Granulocyte-macrophage colony-stimulating factor receptor
UniProt Gene Name:CSF2RA  
UniProt Entry Name:CSF2R_HUMAN
Anti-CSF2RA Antibody (CAB13181)Western blot analysis of extracts of various cell lines, using CSF2RA antibody (CAB13181) at 1:500 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 3s.
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