Cell Biology Antibodies 9
Anti-CSF2 Antibody (CAB6127)
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- SKU:
- CAB6127
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-CSF2 Antibody |
| Antibody SKU: | CAB6127 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 18-144 of human CSF2 (NP_000749.2). |
| Application: | WB IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | Jurkat, A-549, Mouse thymus |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 18-144 of human CSF2 (NP_000749.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | APAR SPSP STQP WEHV NAIQ EARR LLNL SRDT AAEM NETV EVIS EMFD LQEP TCLQ TRLE LYKQ GLRG SLTK LKGP LTMM ASHY KQHC PPTP ETSC ATQI ITFE SFKE NLKD FLLV IPFD CWEP VQE |
| Gene ID: | 1437 |
| Uniprot: | P04141 |
| Cellular Location: | Secreted |
| Calculated MW: | 16kDa |
| Observed MW: | 16kDa |
| Synonyms: | CSF2, GMCSF |
| Background: | The protein encoded by this gene is a cytokine that controls the production, differentiation, and function of granulocytes and macrophages. The active form of the protein is found extracellularly as a homodimer. This gene has been localized to a cluster of related genes at chromosome region 5q31, which is known to be associated with interstitial deletions in the 5q- syndrome and acute myelogenous leukemia. Other genes in the cluster include those encoding interleukins 4, 5, and 13. |
| UniProt Protein Function: | GMCSF: Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes. Belongs to the GM-CSF family. |
| UniProt Protein Details: | Protein type:Secreted, signal peptide; Secreted; Cytokine Chromosomal Location of Human Ortholog: 5q31.1 Cellular Component: extracellular space; extracellular region Molecular Function:protein binding; growth factor activity; granulocyte macrophage colony-stimulating factor receptor binding; cytokine activity Biological Process: negative regulation of cytolysis; epithelial fluid transport; embryonic placenta development; macrophage activation; positive regulation of tyrosine phosphorylation of Stat5 protein; positive regulation of interleukin-23 production; positive regulation of cell proliferation; myeloid dendritic cell differentiation; immune response; positive regulation of DNA replication |
| NCBI Summary: | The protein encoded by this gene is a cytokine that controls the production, differentiation, and function of granulocytes and macrophages. The active form of the protein is found extracellularly as a homodimer. This gene has been localized to a cluster of related genes at chromosome region 5q31, which is known to be associated with interstitial deletions in the 5q- syndrome and acute myelogenous leukemia. Other genes in the cluster include those encoding interleukins 4, 5, and 13. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P04141 |
| NCBI GenInfo Identifier: | 117561 |
| NCBI Gene ID: | 1437 |
| NCBI Accession: | P04141.1 |
| UniProt Secondary Accession: | P04141,Q14CE8, Q2VPI8, Q8NFI6, |
| UniProt Related Accession: | P04141 |
| Molecular Weight: | 16,295 Da |
| NCBI Full Name: | Granulocyte-macrophage colony-stimulating factor |
| NCBI Synonym Full Names: | colony stimulating factor 2 (granulocyte-macrophage) |
| NCBI Official Symbol: | CSF2 |
| NCBI Official Synonym Symbols: | GMCSF |
| NCBI Protein Information: | granulocyte-macrophage colony-stimulating factor; CSF; molgramostin; sargramostim |
| UniProt Protein Name: | Granulocyte-macrophage colony-stimulating factor |
| UniProt Synonym Protein Names: | Colony-stimulating factor; CSF; Molgramostin; Sargramostim |
| Protein Family: | Granulocyte-macrophage colony-stimulating factor |
| UniProt Gene Name: | CSF2 |
| UniProt Entry Name: | CSF2_HUMAN |
 | Western blot analysis of extracts of various cell lines, using CSF2 antibody (CAB6127) at 1:500 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 120s. |
 | Immunofluorescence analysis of C6 cells using CSF2 antibody (CAB6127) at dilution of 1:100. Blue: DAPI for nuclear staining. |
 | Immunofluorescence analysis of L929 cells using CSF2 antibody (CAB6127) at dilution of 1:100. Blue: DAPI for nuclear staining. |
 | Immunofluorescence analysis of U-2 OS cells using CSF2 antibody (CAB6127) at dilution of 1:100. Blue: DAPI for nuclear staining. |
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