Name: Anti-CRY2 Antibody (CAB17465)
Brand: Cell Biology Antibodies 13
SKU: CAB17465
Availability: OutOfStock

Antibody Name:	Anti-CRY2 Antibody
Antibody SKU:	CAB17465
Antibody Size:	20uL, 50uL, 100uL
Application:	WB
Reactivity:	Human, Mouse, Rat
Host Species:	Rabbit
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 36-266 of human CRY2 (NP_066940.2).

Application:	WB
Recommended Dilution:	WB 1:500 - 1:2000
Reactivity:	Human, Mouse, Rat
Positive Samples:	HepG2, Rat lung

Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 36-266 of human CRY2 (NP_066940.2).
Purification Method:	Affinity purification
Storage Buffer:	Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:	IgG
Sequence:	PAPG TDSA SSVH WFRK GLRL HDNP ALLA AVRG ARCV RCVY ILDP WFAA SSSV GINR WRFL LQSL EDLD TSLR KLNS RLFV VRGQ PADV FPRL FKEW GVTR LTFE YDSE PFGK ERDA AIMK MAKE AGVE VVTE NSHT LYDL DRII ELNG QKPP LTYK RFQA IISR MELP KKPV GLVT SQQM ESCR AEIQ ENHD ETYG VPSL EELG FPTE GLGP AVWQ GGET EALA RLDK HLE
Gene ID:	1408
Uniprot:	Q49AN0
Cellular Location:
Calculated MW:	60kDa/66kDa
Observed MW:	67KDa

`- CRY2 Polyclonal Antibody (CAB17465)

Synonyms:

CRY2, HCRY2, PHLL2

Background:

This gene encodes a flavin adenine dinucleotide-binding protein that is a key component of the circadian core oscillator complex, which regulates the circadian clock. This gene is upregulated by CLOCK/ARNTL heterodimers but then represses this upregulation in a feedback loop using PER/CRY heterodimers to interact with CLOCK/ARNTL. Polymorphisms in this gene have been associated with altered sleep patterns. The encoded protein is widely conserved across plants and animals. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2014]

UniProt Protein Function:	CRY2: Blue light-dependent regulator of the circadian feedback loop. Inhibits CLOCK\|NPAS2-ARNTL E box-mediated transcription. Acts, in conjunction with CRY2, in maintaining period length and circadian rhythmicity. Has no photolyase activity. Capable of translocating circadian clock core proteins such as PER proteins to the nucleus. May inhibit CLOCK\|NPAS2-ARNTL transcriptional activity through stabilizing the unphosphorylated form of ARNTL. Belongs to the DNA photolyase class-1 family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:	Protein type:DNA-binding; Lyase Chromosomal Location of Human Ortholog: 11p11.2 Cellular Component: cytoplasm; extracellular region; nucleus Molecular Function:ubiquitin binding; protein binding; DNA binding; DNA (6-4) photolyase activity; damaged DNA binding; deoxyribodipyrimidine photo-lyase activity; blue light photoreceptor activity; single-stranded DNA binding; phosphatase binding Biological Process: circadian rhythm; photoreactive repair; transcription, DNA-dependent; negative regulation of transcription from RNA polymerase II promoter; glucose homeostasis; regulation of circadian rhythm; protein-chromophore linkage; entrainment of circadian clock by photoperiod; blue light signaling pathway; negative regulation of phosphoprotein phosphatase activity; negative regulation of circadian rhythm; circadian regulation of gene expression; negative regulation of transcription, DNA-dependent
NCBI Summary:	This gene encodes a flavin adenine dinucleotide-binding protein that is a key component of the circadian core oscillator complex, which regulates the circadian clock. This gene is upregulated by CLOCK/ARNTL heterodimers but then represses this upregulation in a feedback loop using PER/CRY heterodimers to interact with CLOCK/ARNTL. Polymorphisms in this gene have been associated with altered sleep patterns. The encoded protein is widely conserved across plants and animals. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2014]
UniProt Code:	Q49AN0
NCBI GenInfo Identifier:	118572252
NCBI Gene ID:	1408
NCBI Accession:	Q49AN0.2
UniProt Secondary Accession:	Q49AN0,O75148, Q8IV71, B4DH32, B4DZD6,
UniProt Related Accession:	Q49AN0
Molecular Weight:
NCBI Full Name:	Cryptochrome-2
NCBI Synonym Full Names:	cryptochrome circadian clock 2
NCBI Official Symbol:	CRY2
NCBI Official Synonym Symbols:	HCRY2; PHLL2
NCBI Protein Information:	cryptochrome-2; growth-inhibiting protein 37; cryptochrome 2 (photolyase-like)
UniProt Protein Name:	Cryptochrome-2
Protein Family:	Cryptochrome
UniProt Gene Name:	CRY2
UniProt Entry Name:	CRY2_HUMAN