Cell Biology Antibodies 16

Anti-CRTC2 Antibody (CAB10682)

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SKU:
CAB10682
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-CRTC2 Antibody
Antibody SKU:CAB10682
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 434-693 of human CRTC2 (NP_859066.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 434-693 of human CRTC2 (NP_859066.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:PLSL LAGP ADAR RSQQ QLPK QFSP TMSP TLSS ITQG VPLD TSKL STDQ RLPP YPYS SPSL VLPT QPHT PKSL QQPG LPSQ SCSV QSSG GQPP GRQS HYGT PYPP GPSG HGQQ SYHR PMSD FNLG NLEQ FSME SPSA SLVL DPPG FSEG PGFL GGEG PMGG PQDP HTFN HQNL THCS RHGS GPNI ILTG DSSP GFSK EIAA ALAG VPGF EVSA AGLE LGLG LEDE LRME PLGL EGLN MLSD PCAL LPDP AVEE SFRS DRLQ
Gene ID:200186
Uniprot:Q53ET0
Cellular Location:Cytoplasm, Nucleus
Calculated MW:73kDa
Observed MW:Refer to figures
Synonyms:CRTC2, TORC-2, TORC2
Background:This gene encodes a member of the transducers of regulated cAMP response element-binding protein activity family of transcription coactivators. These proteins promote the transcription of genes targeted by the cAMP response element-binding protein, and therefore play an important role in many cellular processes. Under basal conditions the encoded protein is phosphorylated by AMP-activated protein kinase or the salt-inducible kinases and is sequestered in the cytoplasm. Upon activation by elevated cAMP or calcium, the encoded protein translocates to the nucleus and increases target gene expression. Single nucleotide polymorphisms in this gene may increase the risk of type 2 diabetes. A pseudogene of this gene is located on the long arm of chromosome 5.
UniProt Protein Function:TORC2: the transducer of regulated CREB protein 2 (TORC2) is a cAMP responsive coactivator that, in concert with LKB1 and AMPK, controls glucose homeostasis in the liver. Under fasting conditions, cytoplasmic TORC2 is transported to the nucleus where it binds to CREB and stimulates gluconeogenisis. Re-feeding and the ensuing insulin response inhibits gluconeogenic gene expression by promoting the phosphorylation, cytoplasmic export and degradation of TORC2. TORC2 is phosphorylated by the kinase QIK which in turn is activated by phosphorylation at Ser358 by insulin-activated Akt2. Phosphorylated TORC2 is subsequently ubiquitinylated at Lys 628 and degraded by the 26S proteasome. TORC2 protein levels and activity are increased in diabetes owing to a block in TORC2 phosphorylation, implicating this pathway in the pathogenesis of diabetes. The CREB/TORC2 regulatory axis controls the normal pattern of germinal center (GC) B cell gene activation/repression that promotes B cell development and circumvents GC lymphomagenesis.
UniProt Protein Details:

Protein type:Transcription, coactivator/corepressor

Chromosomal Location of Human Ortholog: 1q21.3

Cellular Component: cytoplasm; nucleoplasm; nucleus

Molecular Function:cAMP response element binding protein binding; protein binding

Biological Process: activation of CREB transcription factor; gluconeogenesis; glucose homeostasis; positive regulation of transcription from RNA polymerase II promoter

NCBI Summary:This gene encodes a member of the transducers of regulated cAMP response element-binding protein activity family of transcription coactivators. These proteins promote the transcription of genes targeted by the cAMP response element-binding protein, and therefore play an important role in many cellular processes. Under basal conditions the encoded protein is phosphorylated by AMP-activated protein kinase or the salt-inducible kinases and is sequestered in the cytoplasm. Upon activation by elevated cAMP or calcium, the encoded protein translocates to the nucleus and increases target gene expression. Single nucleotide polymorphisms in this gene may increase the risk of type 2 diabetes. A pseudogene of this gene is located on the long arm of chromosome 5. [provided by RefSeq, Dec 2010]
UniProt Code:Q53ET0
NCBI GenInfo Identifier:167009135
NCBI Gene ID:200186
NCBI Accession:Q53ET0.2
UniProt Secondary Accession:Q53ET0,Q6UUV8, Q7Z3X7, Q8N332,
UniProt Related Accession:Q53ET0
Molecular Weight:73,302 Da
NCBI Full Name:CREB-regulated transcription coactivator 2
NCBI Synonym Full Names:CREB regulated transcription coactivator 2
NCBI Official Symbol:CRTC2  
NCBI Official Synonym Symbols:TORC2; TORC-2  
NCBI Protein Information:CREB-regulated transcription coactivator 2
UniProt Protein Name:CREB-regulated transcription coactivator 2
UniProt Synonym Protein Names:Transducer of regulated cAMP response element-binding protein 2; TORC-2; Transducer of CREB protein 2
Protein Family:CREB-regulated transcription coactivator
UniProt Gene Name:CRTC2  
UniProt Entry Name:CRTC2_HUMAN
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