Metabolism Antibodies 2

Anti-CROT Antibody (CAB4790)

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SKU:
CAB4790
Product Type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
CROT
Synonyms:
COT
Research Area:
Metabolism

Description

Product Name:CROT Rabbit pAb
Product Code:CAB4790
Size:20uL, 50uL, 100uL
Synonyms:CROT, COT
Applications:WB, IP
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-87 of human CROT (NP_001230674.1).
Applications:WB, IP
Recommended Dilutions:WB 1:500 - 1:2000 IP 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:Rat liver
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-87 of human CROT (NP_001230674.1).
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MENQ LAKS TEER TFQY QDSL PSLP VPSL EESL KKYL ESVK PFAN QEEY KKTE EIVQ KFQS GIGE KLHQ KLLE RAKG KRNW VFVV IIE
Gene ID:54677
Uniprot:Q9UKG9
Cellular Location:Peroxisome
Calculated MW:10kDa/70kDa/73kDa
Observed MW:78kDa
UniProt Protein Function:CROT: Beta-oxidation of fatty acids. The highest activity concerns the C6 to C10 chain length substrate. Converts the end product of pristanic acid beta oxidation, 4,8-dimethylnonanoyl- CoA, to its corresponding carnitine ester. Belongs to the carnitine/choline acetyltransferase family.
UniProt Protein Details:

Protein type:EC 2.3.1.137; Transferase

Chromosomal Location of Human Ortholog: 7q21.1

Cellular Component: peroxisomal matrix; intracellular membrane-bound organelle; mitochondrion; peroxisome

Molecular Function:carnitine O-octanoyltransferase activity; receptor binding

Biological Process: coenzyme A metabolic process; fatty acid beta-oxidation using acyl-CoA oxidase; generation of precursor metabolites and energy; fatty acid beta-oxidation; carnitine metabolic process; cellular lipid metabolic process; fatty acid metabolic process; medium-chain fatty acid metabolic process; fatty acid transport

NCBI Summary:This gene encodes a member of the carnitine/choline acetyltransferase family. The encoded protein converts 4,8-dimethylnonanoyl-CoA to its corresponding carnitine ester. This transesterification occurs in the peroxisome and is necessary for transport of medium- and long- chain acyl-CoA molecules out of the peroxisome to the cytosol and mitochondria. The protein thus plays a role in lipid metabolism and fatty acid beta-oxidation. Alternatively spliced transcript variants have been described.[provided by RefSeq, Jan 2009]
UniProt Code:Q9UKG9
NCBI GenInfo Identifier:48429265
NCBI Gene ID:54677
NCBI Accession:Q9UKG9.2
UniProt Secondary Accession:Q9UKG9,Q86V17, Q8IUW9, Q9Y6I2, A4D1D6, E7EQF2,
UniProt Related Accession:Q9UKG9
Molecular Weight:612
NCBI Full Name:Peroxisomal carnitine O-octanoyltransferase
NCBI Synonym Full Names:carnitine O-octanoyltransferase
NCBI Official Symbol:CROT  
NCBI Official Synonym Symbols:COT  
NCBI Protein Information:peroxisomal carnitine O-octanoyltransferase; peroxisomal carnitine acyltransferase
UniProt Protein Name:Peroxisomal carnitine O-octanoyltransferase
Protein Family:Crotasin
UniProt Gene Name:CROT  
UniProt Entry Name:OCTC_HUMAN
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system_update_altDatasheetHuman CROT Recombinant Protein Carnitine octanoyltransferase (CROT or COT), also known as octanoyl-CoA: L-carnitine O-octanoyltransferase, medium-chain/long-chain carnit