Description
| Product Name: | CROT Rabbit pAb |
| Product Code: | CAB4790 |
| Size: | 20uL, 50uL, 100uL |
| Synonyms: | CROT, COT |
| Applications: | WB, IP |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-87 of human CROT (NP_001230674.1). |
| Applications: | WB, IP |
| Recommended Dilutions: | WB 1:500 - 1:2000 IP 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | Rat liver |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-87 of human CROT (NP_001230674.1). |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MENQ LAKS TEER TFQY QDSL PSLP VPSL EESL KKYL ESVK PFAN QEEY KKTE EIVQ KFQS GIGE KLHQ KLLE RAKG KRNW VFVV IIE |
| Gene ID: | 54677 |
| Uniprot: | Q9UKG9 |
| Cellular Location: | Peroxisome |
| Calculated MW: | 10kDa/70kDa/73kDa |
| Observed MW: | 78kDa |
| UniProt Protein Function: | CROT: Beta-oxidation of fatty acids. The highest activity concerns the C6 to C10 chain length substrate. Converts the end product of pristanic acid beta oxidation, 4,8-dimethylnonanoyl- CoA, to its corresponding carnitine ester. Belongs to the carnitine/choline acetyltransferase family. |
| UniProt Protein Details: | Protein type:EC 2.3.1.137; Transferase Chromosomal Location of Human Ortholog: 7q21.1 Cellular Component: peroxisomal matrix; intracellular membrane-bound organelle; mitochondrion; peroxisome Molecular Function:carnitine O-octanoyltransferase activity; receptor binding Biological Process: coenzyme A metabolic process; fatty acid beta-oxidation using acyl-CoA oxidase; generation of precursor metabolites and energy; fatty acid beta-oxidation; carnitine metabolic process; cellular lipid metabolic process; fatty acid metabolic process; medium-chain fatty acid metabolic process; fatty acid transport |
| NCBI Summary: | This gene encodes a member of the carnitine/choline acetyltransferase family. The encoded protein converts 4,8-dimethylnonanoyl-CoA to its corresponding carnitine ester. This transesterification occurs in the peroxisome and is necessary for transport of medium- and long- chain acyl-CoA molecules out of the peroxisome to the cytosol and mitochondria. The protein thus plays a role in lipid metabolism and fatty acid beta-oxidation. Alternatively spliced transcript variants have been described.[provided by RefSeq, Jan 2009] |
| UniProt Code: | Q9UKG9 |
| NCBI GenInfo Identifier: | 48429265 |
| NCBI Gene ID: | 54677 |
| NCBI Accession: | Q9UKG9.2 |
| UniProt Secondary Accession: | Q9UKG9,Q86V17, Q8IUW9, Q9Y6I2, A4D1D6, E7EQF2, |
| UniProt Related Accession: | Q9UKG9 |
| Molecular Weight: | 612 |
| NCBI Full Name: | Peroxisomal carnitine O-octanoyltransferase |
| NCBI Synonym Full Names: | carnitine O-octanoyltransferase |
| NCBI Official Symbol: | CROT |
| NCBI Official Synonym Symbols: | COT |
| NCBI Protein Information: | peroxisomal carnitine O-octanoyltransferase; peroxisomal carnitine acyltransferase |
| UniProt Protein Name: | Peroxisomal carnitine O-octanoyltransferase |
| Protein Family: | Crotasin |
| UniProt Gene Name: | CROT |
| UniProt Entry Name: | OCTC_HUMAN |
