Cell Biology Antibodies 8
Anti-CRMP1 Antibody (CAB2705)
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- SKU:
- CAB2705
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-CRMP1 Antibody |
| Antibody SKU: | CAB2705 |
| Antibody Size: | 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant protein of human CRMP1 |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:25 - 1:100 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | Mouse brain |
| Immunogen: | Recombinant protein of human CRMP1 |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 1400 |
| Uniprot: | Q14194 |
| Cellular Location: | Cytoplasm, centrosome, cytoskeleton, microtubule organizing center, spindle |
| Calculated MW: | 62kDa/74kDa |
| Observed MW: | 62kDa |
| Synonyms: | CRMP1, CRMP-1, DPYSL1, DRP-1, DRP1, ULIP-3 |
| Background: | This gene encodes a member of a family of cytosolic phosphoproteins expressed exclusively in the nervous system. The encoded protein is thought to be a part of the semaphorin signal transduction pathway implicated in semaphorin-induced growth cone collapse during neural development. Alternative splicing results in multiple transcript variants. |
| UniProt Protein Function: | CRMP-1: Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Belongs to the DHOase family. Hydantoinase/dihydropyrimidinase subfamily. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Cell development/differentiation; Cytoskeletal; Hydrolase Chromosomal Location of Human Ortholog: 4p16.1 Cellular Component: cell soma; cytoplasm; dendrite; microtubule organizing center; spindle; cytosol Molecular Function:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides; protein binding Biological Process: axon guidance; nervous system development; nucleobase, nucleoside, nucleotide and nucleic acid metabolic process; pyrimidine base catabolic process |
| NCBI Summary: | This gene encodes a member of a family of cytosolic phosphoproteins expressed exclusively in the nervous system. The encoded protein is thought to be a part of the semaphorin signal transduction pathway implicated in semaphorin-induced growth cone collapse during neural development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q14194 |
| NCBI GenInfo Identifier: | 3122031 |
| NCBI Gene ID: | 1400 |
| NCBI Accession: | Q14194.1 |
| UniProt Secondary Accession: | Q14194,Q13024, Q4W5F1, Q96TC8, A0EJG6, |
| UniProt Related Accession: | Q14194 |
| Molecular Weight: | 572 |
| NCBI Full Name: | Dihydropyrimidinase-related protein 1 |
| NCBI Synonym Full Names: | collapsin response mediator protein 1 |
| NCBI Official Symbol: | CRMP1 |
| NCBI Official Synonym Symbols: | DRP1; DRP-1; CRMP-1; DPYSL1; ULIP-3 |
| NCBI Protein Information: | dihydropyrimidinase-related protein 1; dihydropyrimidinase-like 1; unc-33-like phosphoprotein 3 |
| UniProt Protein Name: | Dihydropyrimidinase-related protein 1 |
| UniProt Synonym Protein Names: | Collapsin response mediator protein 1; CRMP-1; Unc-33-like phosphoprotein 3; ULIP-3 |
| Protein Family: | Dihydropyrimidinase-related protein |
| UniProt Gene Name: | CRMP1 |
| UniProt Entry Name: | DPYL1_HUMAN |
 | Western blot analysis of extracts of mouse brain, using CRMP1 antibody (CAB2705). Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. |
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