Metabolism Antibodies 1

Anti-CRLS1 Antibody (CAB12388)

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SKU:
CAB12388
Product Type:
Antibody
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Metabolism

Description

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Antibody Name:Anti-CRLS1 Antibody
Antibody SKU:CAB12388
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-110 of human CRLS1 (NP_061968.1).
Application:WB
Recommended Dilution:WB 1:200 - 1:500
Reactivity:Mouse
Positive Samples:Mouse liver
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-110 of human CRLS1 (NP_061968.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MLAL RVAR GSWG ALRG AAWA PGTR PSKR RACW ALLP PVPC CLGC LAER WRLR PAAL GLRL PGIG QRNH CSGA GKAA PRPA AGAG AAAE APGG QWGP ASTP SLYE NPWT IP
Gene ID:54675
Uniprot:Q9UJA2
Cellular Location:Mitochondrion inner membrane, Multi-pass membrane protein
Calculated MW:22kDa/32kDa
Observed MW:36kDa
Synonyms:CRLS1, C20orf155, CLS, CLS1, GCD10, dJ967N21.6
Background:This gene encodes a member of the CDP-alcohol phosphatidyltransferase class-I family of proteins. The encoded enzyme catalyzes the synthesis of cardiolipin, a phospholipid component of mitochondrial membranes that is critical for mitochondrial function.
UniProt Protein Function:CRLS1: Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol. Belongs to the CDP-alcohol phosphatidyltransferase class-I family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:EC 2.7.8.-; Lipid Metabolism - glycerophospholipid; Membrane protein, integral; Membrane protein, multi-pass; Mitochondrial; Transferase

Chromosomal Location of Human Ortholog: 20p12.3

Cellular Component: mitochondrial inner membrane; mitochondrion

Molecular Function:1-acylglycerol-3-phosphate O-acyltransferase activity; 2-acylglycerol-3-phosphate O-acyltransferase activity; cardiolipin synthase activity; CDP-diacylglycerol-phosphatidylglycerol phosphatidyltransferase activity

Biological Process: cardiolipin biosynthetic process

NCBI Summary:This gene encodes a member of the CDP-alcohol phosphatidyltransferase class-I family of proteins. The encoded enzyme catalyzes the synthesis of cardiolipin, a phospholipid component of mitochondrial membranes that is critical for mitochondrial function. [provided by RefSeq, Apr 2016]
UniProt Code:Q9UJA2
NCBI GenInfo Identifier:37537857
NCBI Gene ID:54675
NCBI Accession:Q9UJA2.1
UniProt Secondary Accession:Q9UJA2,Q27RP0, Q69YQ5, D3DW09, E9PAT4,
UniProt Related Accession:Q9UJA2
Molecular Weight:33kDa
NCBI Full Name:Cardiolipin synthase (CMP-forming)
NCBI Synonym Full Names:cardiolipin synthase 1
NCBI Official Symbol:CRLS1  
NCBI Official Synonym Symbols:CLS; CLS1; GCD10; C20orf155; dJ967N21.6  
NCBI Protein Information:cardiolipin synthase (CMP-forming)
UniProt Protein Name:Cardiolipin synthase (CMP-forming)
UniProt Synonym Protein Names:Protein GCD10 homolog
UniProt Gene Name:CRLS1  
Anti-CRLS1 Antibody (CAB12388)Western blot analysis of extracts of mouse liver, using CRLS1 antibody (CAB12388) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 60s.
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