Cell Biology Antibodies 17
Anti-CRKII Antibody (CAB9577)
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- SKU:
- CAB9577
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Monoclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-CRKII Antibody |
| Antibody SKU: | CAB9577 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human CRKII |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse |
| Positive Samples: | 293T, A-549, Mouse lung |
| Immunogen: | A synthesized peptide derived from human CRKII |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 1398 |
| Uniprot: | P46108 |
| Cellular Location: | |
| Calculated MW: | 38kDa |
| Observed MW: | 37KDa |
| Synonyms: | CRKII, p38 |
| Background: | This gene encodes a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. The product of this gene has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction. The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation. Two alternative transcripts encoding different isoforms with distinct biological activity have been described. [provided by RefSeq, Jul 2008] |
| UniProt Protein Function: | CRK: an adaptor protein with an SH2-SH3-SH3 domain structure. Recruits cytoplasmic proteins through SH2-phospho-tyrosine interaction. Phosphorylated by Abl, IGF-IR and EGFR. Phosphorylation induces a change in intramolecular folding and SH2 interactions, causing its rapid dissociation from the tyrosine kinase complex. |
| UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; Adaptor/scaffold; Oncoprotein Chromosomal Location of Human Ortholog: 17p13.3 Cellular Component: cytoplasm; plasma membrane; cytosol; nucleus; actin cytoskeleton Molecular Function:protein phosphorylated amino acid binding; protein binding; ephrin receptor binding; SH3/SH2 adaptor activity; SH2 domain binding Biological Process: regulation of transcription from RNA polymerase II promoter; regulation of Rac protein signal transduction; platelet activation; activation of MAPKK activity; nerve growth factor receptor signaling pathway; regulation of actin cytoskeleton organization and biogenesis; insulin receptor signaling pathway; ephrin receptor signaling pathway; innate immune response; vascular endothelial growth factor receptor signaling pathway; blood coagulation |
| NCBI Summary: | This gene encodes a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. The product of this gene has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction. The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation. Two alternative transcripts encoding different isoforms with distinct biological activity have been described. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P46108 |
| NCBI GenInfo Identifier: | 158939322 |
| NCBI Gene ID: | 1398 |
| NCBI Accession: | P46108.2 |
| UniProt Secondary Accession: | P46108,Q96GA9, Q96HJ0, A8MWE8, B0LPE8, D3DTH6, |
| UniProt Related Accession: | P46108 |
| Molecular Weight: | 304 |
| NCBI Full Name: | Adapter molecule crk |
| NCBI Synonym Full Names: | v-crk avian sarcoma virus CT10 oncogene homolog |
| NCBI Official Symbol: | CRK |
| NCBI Official Synonym Symbols: | p38; CRKII |
| NCBI Protein Information: | adapter molecule crk; proto-oncogene c-Crk |
| UniProt Protein Name: | Adapter molecule crk |
| UniProt Synonym Protein Names: | Proto-oncogene c-Crk; p38 |
| Protein Family: | Crk-like protein |
| UniProt Gene Name: | CRK |
| UniProt Entry Name: | CRK_HUMAN |
 | Western blot - CRKII Rabbit mAb (CAB9577) |
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