Cell Biology Antibodies 3
Anti-CRHR2 Antibody (CAB12428)
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- SKU:
- CAB12428
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-CRHR2 Antibody |
| Antibody SKU: | CAB12428 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 25-140 of human CRHR2 (NP_001189404.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | U-87MG, B cells, Mouse lung, Mouse brain, Rat brain |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 25-140 of human CRHR2 (NP_001189404.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | PPPL QYAA GQSQ MPKD QPLW ALLE QYCH TIMT LTNL SGPY SYCN TTLD QIGT CWPR SAAG ALVE RPCP EYFN GVKY NTTR NAYR ECLE NGTW ASKI NYSQ CEPI LDDK QRKY DLHY |
| Gene ID: | 1395 |
| Uniprot: | Q13324 |
| Cellular Location: | Cell membrane, Multi-pass membrane protein |
| Calculated MW: | 42kDa/44kDa/46kDa/47kDa/50kDa |
| Observed MW: | 47kDa |
| Synonyms: | CRHR2, CRF-RB, CRF2, CRFR2, HM-CRF |
| Background: | The protein encoded by this gene belongs to the G-protein coupled receptor 2 family, and the subfamily of corticotropin releasing hormone receptor. This receptor shows high affinity for corticotropin releasing hormone (CRH), and also binds CRH-related peptides such as urocortin. CRH is synthesized in the hypothalamus, and plays an important role in coordinating the endocrine, autonomic, and behavioral responses to stress and immune challenge. Studies in mice suggest that this receptor maybe involved in mediating cardiovascular homeostasis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. |
| UniProt Protein Function: | CRHR2: This is a receptor for corticotropin releasing factor. Shows high-affinity CRF binding. Also binds to urocortin I, II and III. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 2 family. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Receptor, GPCR; Membrane protein, integral; GPCR, family 2; Membrane protein, multi-pass Chromosomal Location of Human Ortholog: 7p14.3 Cellular Component: integral to plasma membrane; plasma membrane Molecular Function:corticotrophin-releasing factor receptor activity; protein binding Biological Process: G-protein signaling, coupled to cAMP nucleotide second messenger |
| NCBI Summary: | The protein encoded by this gene belongs to the G-protein coupled receptor 2 family, and the subfamily of corticotropin releasing hormone receptor. This receptor shows high affinity for corticotropin releasing hormone (CRH), and also binds CRH-related peptides such as urocortin. CRH is synthesized in the hypothalamus, and plays an important role in coordinating the endocrine, autonomic, and behavioral responses to stress and immune challenge. Studies in mice suggest that this receptor maybe involved in mediating cardiovascular homeostasis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jan 2011] |
| UniProt Code: | Q13324 |
| NCBI GenInfo Identifier: | 6226847 |
| NCBI Gene ID: | 1395 |
| NCBI Accession: | Q13324.2 |
| UniProt Secondary Accession: | Q13324,O43461, Q4QRJ4, Q99431, B2R967, B3SXS6, B3SXS7 B3SXS8, B3SXT0, F8WA81, |
| UniProt Related Accession: | Q13324 |
| Molecular Weight: | 47,560 Da |
| NCBI Full Name: | Corticotropin-releasing factor receptor 2 |
| NCBI Synonym Full Names: | corticotropin releasing hormone receptor 2 |
| NCBI Official Symbol: | CRHR2 |
| NCBI Official Synonym Symbols: | CRF2; CRFR2; CRF-RB; HM-CRF |
| NCBI Protein Information: | corticotropin-releasing factor receptor 2 |
| UniProt Protein Name: | Corticotropin-releasing factor receptor 2 |
| UniProt Synonym Protein Names: | Corticotropin-releasing hormone receptor 2; CRH-R-2; CRH-R2 |
| Protein Family: | Corticotropin-releasing factor receptor |
| UniProt Gene Name: | CRHR2 |
| UniProt Entry Name: | CRFR2_HUMAN |
 | Western blot analysis of extracts of various cell lines, using CRHR2 antibody (CAB12428) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 60s. |
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