Cell Biology Antibodies 4

Anti-CREBBP Antibody (CAB14237)

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SKU:
CAB14237
Product Type:
Antibody
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-CREBBP Antibody
Antibody SKU:CAB14237
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC
Reactivity:Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant protein of mouse CREBBP
Application:WB IHC
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:50 - 1:200
Reactivity:Mouse, Rat
Positive Samples:Mouse brain, Rat brain
Immunogen:Recombinant protein of mouse CREBBP
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:12914
Uniprot:Q6GQV9
Cellular Location:Cytoplasm, Nucleus
Calculated MW:172kDa
Observed MW:300kDa
Synonyms:CREBBP, CBP, KAT3A, RSTS, RSTS1
Background:This gene is ubiquitously expressed and is involved in the transcriptional coactivation of many different transcription factors. First isolated as a nuclear protein that binds to cAMP-response element binding protein (CREB), this gene is now known to play critical roles in embryonic development, growth control, and homeostasis by coupling chromatin remodeling to transcription factor recognition. The protein encoded by this gene has intrinsic histone acetyltransferase activity and also acts as a scaffold to stabilize additional protein interactions with the transcription complex. This protein acetylates both histone and non-histone proteins. This protein shares regions of very high sequence similarity with protein p300 in its bromodomain, cysteine-histidine-rich regions, and histone acetyltransferase domain. Mutations in this gene cause Rubinstein-Taybi syndrome (RTS). Chromosomal translocations involving this gene have been associated with acute myeloid leukemia. Alternative splicing results in multiple transcript variants encoding different isoforms.
UniProt Code:Q6GQV9
NCBI GenInfo Identifier:81884771
NCBI Gene ID:12914
NCBI Accession:
UniProt Related Accession:P45481
Molecular Weight:172kDa
NCBI Full Name:Crebbp protein
NCBI Synonym Full Names:CREB binding protein
NCBI Official Symbol:Crebbp  
NCBI Official Synonym Symbols:CBP; KAT3A; AW558298; CBP/p300; p300/CBP  
NCBI Protein Information:CREB-binding protein
UniProt Protein Name:
Protein Family:CREB-binding protein
UniProt Gene Name:
Anti-CREBBP Antibody (CAB14237)Western blot analysis of extracts of various cell lines, using CREBBP antibody (CAB14237) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 10s.
Anti-CREBBP Antibody (CAB14237)Immunohistochemistry of paraffin-embedded rat testis using CREBBP antibody (CAB14237) at dilution of 1:100 (40x lens).
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