Epigenetics & Nuclear Signaling Antibodies 3

Anti-CREB3L3 Antibody (CAB16655)

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SKU:
CAB16655
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Epigenetics and Nuclear Signaling

Description

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Antibody Name:Anti-CREB3L3 Antibody
Antibody SKU:CAB16655
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 371-460 of human CREB3L3 (NP_001258924.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Rat
Positive Samples:HepG2
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 371-460 of human CREB3L3 (NP_001258924.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:AADA VPGS EAPG PRPE ADTT REES PGSP GADW GFQD TANL TNST EELD NATL VLRN ATEG LGQV ALLD WVAP GPST GSGR AGLE AAGD EL
Gene ID:84699
Uniprot:Q68CJ9
Cellular Location:
Calculated MW:35kDa/48kDa/49kDa
Observed MW:70KDa
Synonyms:CREB3L3, CREB-H, CREBH, HYST1481
Background:This gene encodes a member of the basic-leucine zipper family and the AMP-dependent transcription factor family. The encoded protein is localized to the endoplasmic reticulum and acts as a transcription factor activated by cyclic AMP stimulation. The encoded protein binds the cyclic AMP response element (CRE) and the box-B element and has been linked to acute inflammatory response, hepatocellular carcinoma, triglyceride metabolism, and hepcidin expression. Alternative splicing results in multiple transcript variants.
UniProt Protein Function:CREB3L3: Transcription factor that may act during endoplasmic reticulum stress by activating unfolded protein response target genes. Activated in response to cAMP stimulation. In vitro, binds to the cAMP response element (CRE) and box-B element. Activates transcription through box-B element. Activates transcription through CRE. Seems to function synergistically with ATF6. In acute inflammatory response, may activate expression of acute phase response (APR) genes. May be involved in growth suppression. Belongs to the bZIP family. ATF subfamily. Binds DNA as a dimer. Probably homodimerizes. Probably forms a heterodimer with ATF6. Interacts with ATF6. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Membrane protein, integral; Transcription factor

Chromosomal Location of Human Ortholog: 19p13.3

Cellular Component: endoplasmic reticulum; membrane; nucleus

Molecular Function:protein binding; protein heterodimerization activity; protein homodimerization activity

Biological Process: positive regulation of transcription from RNA polymerase II promoter

NCBI Summary:This gene encodes a member of the basic-leucine zipper family and the AMP-dependent transcription factor family. The encoded protein is localized to the endoplasmic reticulum and acts as a transcription factor activated by cyclic AMP stimulation. The encoded protein binds the cyclic AMP response element (CRE) and the box-B element and has been linked to acute inflammatory response, hepatocellular carcinoma, triglyceride metabolism, and hepcidin expression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]
UniProt Code:Q68CJ9
NCBI GenInfo Identifier:148886847
NCBI Gene ID:84699
NCBI Accession:Q68CJ9.2
UniProt Secondary Accession:Q68CJ9,Q6ZMC5, Q96TB9, B2R7S6, B7ZL69, M0QYW7,
UniProt Related Accession:Q68CJ9
Molecular Weight:35,845 Da
NCBI Full Name:Cyclic AMP-responsive element-binding protein 3-like protein 3
NCBI Synonym Full Names:cAMP responsive element binding protein 3 like 3
NCBI Official Symbol:CREB3L3  
NCBI Official Synonym Symbols:CREBH; CREB-H; HYST1481  
NCBI Protein Information:cyclic AMP-responsive element-binding protein 3-like protein 3
UniProt Protein Name:Cyclic AMP-responsive element-binding protein 3-like protein 3
UniProt Synonym Protein Names:Transcription factor CREB-H
Protein Family:Cyclic AMP-responsive element-binding protein 3-like protein
UniProt Gene Name:CREB3L3  
UniProt Entry Name:CR3L3_HUMAN
Anti-CREB3L3 Antibody (CAB16655)Western blot analysis of extracts of HepG2 cells, using CREB3L3 antibody (CAB16655) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
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