Epigenetics & Nuclear Signaling Antibodies 1

Anti-CREB3L2 Antibody (CAB10554)

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SKU:
CAB10554
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Epigenetics and Nuclear Signaling

Description

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Antibody Name:Anti-CREB3L2 Antibody
Antibody SKU:CAB10554
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-247 of human CREB3L2 (NP_001240704.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Rat
Positive Samples:HepG2
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-247 of human CREB3L2 (NP_001240704.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MEVL ESGE QGVL QWDR KLSE LSEP GDGE ALMY HTHF SELL DEFS QNVL GQLL NDPF LSEK SVSM EVEP SPTS PAPL IQAE HSYS LCEE PRAQ SPFT HITT SDSF NDDE VESE KWYL STDF PSTS IKTE PVTD EPPP GLVP SVTL TITA ISTP LEKE EPPL EMNT GVDS SCQT IIPK IKLE PHEV DQFL NFSP KEGL SALP VSLW VMDM VSGS TERE YGER AGMS LYHR CCSW LYEI ALFL KNKN FAS
Gene ID:64764
Uniprot:Q70SY1
Cellular Location:Endoplasmic reticulum membrane, Nucleus, Single-pass type II membrane protein
Calculated MW:27kDa/50kDa/57kDa
Observed MW:57kDa
Synonyms:CREB3L2, BBF2H7
Background:This gene encodes a member of the oasis bZIP transcription factor family. Members of this family can dimerize but form homodimers only. The encoded protein is a transcriptional activator. Translocations between this gene on chromosome 7 and the gene fused in sarcoma on chromosome 16 can be found in some tumors. Multiple transcript variants encoding different isoforms have been found for this gene.
UniProt Protein Function:CREB3L2: Transcriptional activator which is processed and activated during endoplasmic reticulum stress late phase. Binds to the cAMP response element (CRE) and activates transcription through CRE. Regulates the transcription of unfolded protein response target genes, preventing accumulation of unfolded proteins in damaged neurons. Also regulates the expression of SEC23A, accelerating protein trafficking from the ER to the Golgi thereby playing a key role in chondrocyte differentiation and formation of epiphyseal cartilage. A chromosomal aberration involving CREB3L2 is found in low grade fibromyxoid sarcoma (LGFMS). Translocation t(7;16)(q33;p11) with FUS. Belongs to the bZIP family. ATF subfamily. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Membrane protein, integral; Oncoprotein; Transcription factor

Chromosomal Location of Human Ortholog: 7q33

Cellular Component: endoplasmic reticulum; nucleoplasm; nucleus

Biological Process: cartilage development; chondrocyte differentiation; positive regulation of transcription, DNA-dependent

NCBI Summary:This gene encodes a member of the oasis bZIP transcription factor family. Members of this family can dimerize but form homodimers only. The encoded protein is a transcriptional activator. Translocations between this gene on chromosome 7 and the gene fused in sarcoma on chromosome 16 can be found in some tumors. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
UniProt Code:Q70SY1
NCBI GenInfo Identifier:296439387
NCBI Gene ID:64764
NCBI Accession:Q70SY1.3
UniProt Secondary Accession:Q70SY1,Q6P454, Q6ZMR6,
UniProt Related Accession:Q70SY1
Molecular Weight:57kDa
NCBI Full Name:Cyclic AMP-responsive element-binding protein 3-like protein 2
NCBI Synonym Full Names:cAMP responsive element binding protein 3 like 2
NCBI Official Symbol:CREB3L2  
NCBI Official Synonym Symbols:BBF2H7  
NCBI Protein Information:cyclic AMP-responsive element-binding protein 3-like protein 2
UniProt Protein Name:Cyclic AMP-responsive element-binding protein 3-like protein 2
UniProt Synonym Protein Names:BBF2 human homolog on chromosome 7
Protein Family:Cyclic AMP-responsive element-binding protein 3-like protein
UniProt Gene Name:CREB3L2  
Anti-CREB3L2 Antibody (CAB10554)Western blot analysis of extracts of HepG2 cells, using CREB3L2 antibody (CAB10554) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s.
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