Signal Transduction Antibodies 2
Anti-CRBN Antibody (CAB4722)
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- SKU:
- CAB4722
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- CRBN
- Synonyms:
- MRT2
- Synonyms:
- MRT2A
- Synonyms:
- cereblon
Description
| Product Name: | CRBN Rabbit pAb |
| Product Code: | CAB4722 |
| Size: | 20uL, 50uL, 100uL |
| Synonyms: | CRBN, MRT2, MRT2A, cereblon |
| Applications: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-280 of human CRBN (NP_001166953.1). |
| Applications: | WB |
| Recommended Dilutions: | WB 1:200 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | U-87MG, A-549, Mouse brain, Rat brain |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-280 of human CRBN (NP_001166953.1). |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MAGE GDQQ DAAH NMGN HLPL LPES EEED EMEV EDQD SKEA KKPN IINF DTSL PTSH TYLG ADME EFHG RTLH DDDS CQVI PVLP QVMM ILIP GQTL PLQL FHPQ EVSM VRNL IQKD RTFA VLAY SNVQ EREA QFGT TAEI YAYR EEQD FGIE IVKV KAIG RQRF KVLE LRTQ SDGI QQAK VQIL PECV LPST MSAV QLES LNKC QIFP SKPV SRED QCSY KWWQ KYQK RKFH CANL TSWP RWLY SLYD AETL MDRI KKQL REWD ENLK DDSL PSNP IDFS |
| Gene ID: | 51185 |
| Uniprot: | Q96SW2 |
| Cellular Location: | Cytoplasm, Membrane, Nucleus, Peripheral membrane protein |
| Calculated MW: | 50kDa |
| Observed MW: | 55KDa |
| UniProt Protein Function: | CRBN: Component of some DCX (DDB1-CUL4-X-box) E3 protein ligase complex, a complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins and is required for limb outgrowth and expression of the fibroblast growth factor FGF8. In the complex, may act as a substrate receptor. Regulates the assembly and neuronal surface expression of large-conductance calcium-activated potassium channels in brain regions involved in memory and learning via its interaction with KCNT1. Defects in CRBN are the cause of mental retardation autosomal recessive type 2A (MRT2A). MRT2A patients display mild mental retardation with a standard IQ ranged from 50 to 70. IQ scores are lower in males than females. Developmental milestones are mildly delayed. There are no dysmorphic or autistic features. Non-syndromic mental retardation patients do not manifest other clinical signs. Belongs to the CRBN family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Ubiquitin conjugating system Chromosomal Location of Human Ortholog: 3p26.2 Cellular Component: membrane; cytoplasm; nucleolus; nucleus Molecular Function:protein binding; ATP-dependent peptidase activity; metal ion binding Biological Process: proteasomal ubiquitin-dependent protein catabolic process; protein ubiquitination; negative regulation of protein homooligomerization Disease: Mental Retardation, Autosomal Recessive 2 |
| NCBI Summary: | This gene encodes a protein related to the Lon protease protein family. In rodents and other mammals this gene product is found in the cytoplasm localized with a calcium channel membrane protein, and is thought to play a role in brain development. Mutations in this gene are associated with autosomal recessive nonsyndromic mental retardation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010] |
| UniProt Code: | Q96SW2 |
| NCBI GenInfo Identifier: | 73918916 |
| NCBI Gene ID: | 51185 |
| NCBI Accession: | Q96SW2.1 |
| UniProt Secondary Accession: | Q96SW2,Q6AI62, Q6NVZ0, Q9UHW4, B2R6H4, C9IZA9, C9JAH6 |
| UniProt Related Accession: | Q96SW2 |
| Molecular Weight: | 442 |
| NCBI Full Name: | Protein cereblon |
| NCBI Synonym Full Names: | cereblon |
| NCBI Official Symbol: | CRBN |
| NCBI Official Synonym Symbols: | MRT2; MRT2A |
| NCBI Protein Information: | protein cereblon; protein x 0001 |
| UniProt Protein Name: | Protein cereblon |
| Protein Family: | Protein cereblon |
| UniProt Gene Name: | CRBN |
| UniProt Entry Name: | CRBN_HUMAN |
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