Signal Transduction Antibodies 3
Anti-CRALBP Antibody (CAB9265)
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- SKU:
- CAB9265
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Monoclonal Antibody
- Research Area:
- Signal Transduction
Description
| Antibody Name: | Anti-CRALBP Antibody |
| Antibody SKU: | CAB9265 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human CRALBP |
| Application: | WB IHC IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | Mouse eye |
| Immunogen: | A synthesized peptide derived from human CRALBP |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 6017 |
| Uniprot: | P12271 |
| Cellular Location: | |
| Calculated MW: | 36kDa |
| Observed MW: | 36KDa |
| Synonyms: | CRALBP |
| Background: | The protein encoded by this gene is a 36-kD water-soluble protein which carries 11-cis-retinaldehyde or 11-cis-retinal as physiologic ligands. It may be a functional component of the visual cycle. Mutations of this gene have been associated with severe rod-cone dystrophy, Bothnia dystrophy (nonsyndromic autosomal recessive retinitis pigmentosa) and retinitis punctata albescens. [provided by RefSeq, Jul 2008] |
| UniProt Protein Function: | RLBP1: Soluble retinoid carrier essential the proper function of both rod and cone photoreceptors. Participates in the regeneration of active 11-cis-retinol and 11-cis-retinaldehyde, from the inactive 11-trans products of the rhodopsin photocycle and in the de novo synthesis of these retinoids from 11-trans metabolic precursors. The cycling of retinoids between photoreceptor and adjacent pigment epithelium cells is known as the 'visual cycle'. Defects in RLBP1 are a cause of retinitis pigmentosa autosomal recessive (ARRP). RP leads to degeneration of retinal photoreceptor cells. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. Defects in RLBP1 are the cause of Bothnia retinal dystrophy (BRD); also known as Vasterbotten dystrophy. Affected individuals show night blindness from early childhood with features consistent with retinitis punctata albescens and macular degeneration. Defects in RLBP1 are the cause of rod-cone dystrophy Newfoundland (NFRCD). NFRCD is a retinal dystrophy reminiscent of retinitis punctata albescens but with a substantially lower age at onset and more-rapid and distinctive progression. Rod-cone dystrophies results from initial loss of rod photoreceptors, later followed by cone photoreceptors loss. Defects in RLBP1 are a cause of retinitis punctata albescens (RPA). A rare form of stationary night blindness characterized by a delay in the regeneration of cone and rod photopigments. |
| UniProt Protein Details: | Chromosomal Location of Human Ortholog: 15q26 Cellular Component: cytosol Biological Process: retinoid metabolic process; vitamin A metabolic process Disease: Bothnia Retinal Dystrophy; Fundus Albipunctatus; Newfoundland Rod-cone Dystrophy |
| NCBI Summary: | The protein encoded by this gene is a 36-kD water-soluble protein which carries 11-cis-retinaldehyde or 11-cis-retinal as physiologic ligands. It may be a functional component of the visual cycle. Mutations of this gene have been associated with severe rod-cone dystrophy, Bothnia dystrophy (nonsyndromic autosomal recessive retinitis pigmentosa) and retinitis punctata albescens. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P12271 |
| NCBI GenInfo Identifier: | 117391 |
| NCBI Gene ID: | 6017 |
| NCBI Accession: | P12271.2 |
| UniProt Secondary Accession: | P12271,B2R667, |
| UniProt Related Accession: | P12271 |
| Molecular Weight: | 36,474 Da |
| NCBI Full Name: | Retinaldehyde-binding protein 1 |
| NCBI Synonym Full Names: | retinaldehyde binding protein 1 |
| NCBI Official Symbol: | RLBP1 |
| NCBI Official Synonym Symbols: | CRALBP |
| NCBI Protein Information: | retinaldehyde-binding protein 1 |
| UniProt Protein Name: | Retinaldehyde-binding protein 1 |
| UniProt Synonym Protein Names: | Cellular retinaldehyde-binding protein |
| Protein Family: | Retinaldehyde-binding protein |
| UniProt Gene Name: | RLBP1 |
| UniProt Entry Name: | RLBP1_HUMAN |
 | Western blot - CRALBP Rabbit mAb (CAB9265) |
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