Immunology Antibodies 3
Anti-CR2 Antibody (CAB8407)
- SKU:
- CAB8407
- Product Type:
- Antibody
- Applications:
- WB
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Immunology
Description
| Antibody Name: | Anti-CR2 Antibody |
| Antibody SKU: | CAB8407 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 300-590 of human CR2 (NP_001006659.1). |
| Application: | WB IHC IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:100 IF 1:50 - 1:100 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | B-cell, 293T, Jurkat, Mouse spleen, Mouse liver, Rat liver |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 300-590 of human CR2 (NP_001006659.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | IVTY TCDP DPEE GVNF ILIG ESTL RCTV DSQK TGTW SGPA PRCE LSTS AVQC PHPQ ILRG RMVS GQKD RYTY NDTV IFAC MFGF TLKG SKQI RCNA QGTW EPSA PVCE KECQ APPN ILNG QKED RHMV RFDP GTSI KYSC NPGY VLVG EESI QCTS EGVW TPPV PQCK VAAC EATG RQLL TKPQ HQFV RPDV NSSC GEGY KLSG SVYQ ECQG TIPW FMEI RLCK EITC PPPP VIYN GAHT GSSL EDFP YGTT VTYT CNPG PERG VEFS LIGE STIR CTSN DQER GTWS GPA |
| Gene ID: | 1380 |
| Uniprot: | P20023 |
| Cellular Location: | Membrane, Single-pass type I membrane protein |
| Calculated MW: | 110kDa/112kDa/118kDa/119kDa |
| Observed MW: | 113kDa |
| Synonyms: | CR2, C3DR, CD21, CR, CVID7, SLEB9 |
| Background: | This gene encodes a membrane protein, which functions as a receptor for Epstein-Barr virus (EBV) binding on B and T lymphocytes. Genetic variations in this gene are associated with susceptibility to systemic lupus erythematosus type 9 (SLEB9). Alternatively spliced transcript variants encoding different isoforms have been found for this gene. |
| UniProt Protein Function: | CR2: Receptor for complement C3Dd, for the Epstein-Barr virus on human B-cells and T-cells and for HNRPU. Participates in B lymphocytes activation. Genetic variations in CR2 are associated with susceptibility to systemic lupus erythematosus type 9 (SLEB9). Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with a complex genetic basis. SLE is an inflammatory, and often febrile multisystemic disorder of connective tissue characterized principally by involvement of the skin, joints, kidneys, and serosal membranes. It is thought to represent a failure of the regulatory mechanisms of the autoimmune system. Defects in CR2 are the cause of immunodeficiency, common variable, type 7 (CVID7). A primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B cells is usually in the normal range, but can be low. Belongs to the receptors of complement activation (RCA) family. 4 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Receptor, misc. Chromosomal Location of Human Ortholog: 1q32 Cellular Component: receptor complex Molecular Function:complement binding; DNA binding; protein homodimerization activity Biological Process: B cell differentiation; B cell proliferation Disease: Immunodeficiency, Common Variable, 2; Immunodeficiency, Common Variable, 7; Systemic Lupus Erythematosus, Susceptibility To, 9 |
| NCBI Summary: | This gene encodes a membrane protein, which functions as a receptor for Epstein-Barr virus (EBV) binding on B and T lymphocytes. Genetic variations in this gene are associated with susceptibility to systemic lupus erythematosus type 9 (SLEB9). Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009] |
| UniProt Code: | P20023 |
| NCBI GenInfo Identifier: | 215273962 |
| NCBI Gene ID: | 1380 |
| NCBI Accession: | P20023.2 |
| UniProt Secondary Accession: | P20023,Q13866, Q14212, Q53EL2, Q5BKT9, Q5SR46, Q5SR48 C9JHD2, |
| UniProt Related Accession: | P20023 |
| Molecular Weight: | |
| NCBI Full Name: | Complement receptor type 2 |
| NCBI Synonym Full Names: | complement component 3d receptor 2 |
| NCBI Official Symbol: | CR2 |
| NCBI Official Synonym Symbols: | CR; C3DR; CD21; CVID7; SLEB9 |
| NCBI Protein Information: | complement receptor type 2 |
| UniProt Protein Name: | Complement receptor type 2 |
| UniProt Synonym Protein Names: | Complement C3d receptor; Epstein-Barr virus receptor; EBV receptor; CD_antigen: CD21 |
| Protein Family: | Complement receptor |
| UniProt Gene Name: | CR2 |
| UniProt Entry Name: | CR2_HUMAN |
 | Western blot analysis of extracts of various cell lines, using CR2 antibody (CAB8407) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 15s. |
 | Immunohistochemistry of paraffin-embedded rat spleen using CR2 antibody (CAB8407) at dilution of 1:100 (40x lens). |
 | Immunofluorescence analysis of rat spleen using Anti-CR2 Polyclonal Antibody (CAB8407) at dilution of 1:100 (40x lens). Blue: DAPI for nuclear staining. |
 | Immunofluorescence analysis of human spleen using Anti-CR2 Polyclonal Antibody (CAB8407) at dilution of 1:100 (40x lens). Blue: DAPI for nuclear staining. |
 | Immunofluorescence analysis of mouse spleen using Anti-CR2 Polyclonal Antibody (CAB8407) at dilution of 1:100 (40x lens). Blue: DAPI for nuclear staining. |
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