Cell Biology Antibodies 13
Anti-CPSF1 Antibody (CAB17144)
- SKU:
- CAB17144
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
Antibody Name: | Anti-CPSF1 Antibody |
Antibody SKU: | CAB17144 |
Antibody Size: | 20uL, 50uL, 100uL |
Application: | WB |
Reactivity: | Human, Mouse |
Host Species: | Rabbit |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 700-950 of human CPSF1 (NP_037423.2). |
Application: | WB |
Recommended Dilution: | WB 1:500 - 1:2000 |
Reactivity: | Human, Mouse |
Positive Samples: | 293T, NIH/3T3, Mouse liver |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 700-950 of human CPSF1 (NP_037423.2). |
Purification Method: | Affinity purification |
Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Isotype: | IgG |
Sequence: | LYRD LSGM FTTE SRLG GARD ELGG RSGP EAEG LGSE TSPT VDDE EEML YGDS GSLF SPSK EEAR RSSQ PPAD RDPA PFRA EPTH WCLL VREN GTME IYQL PDWR LVFL VKNF PVGQ RVLV DSSF GQPT TQGE ARRE EATR QGEL PLVK EVLL VALG SRQS RPYL LVHV DQEL LIYE AFPH DSQL GQGN LKVR FKKV PHNI NFRE KKPK PSKK KAEG GGAE EGAG ARGR VARF RYFE DIYG YSGV FICG PSP |
Gene ID: | 29894 |
Uniprot: | Q10570 |
Cellular Location: | |
Calculated MW: | 160kDa |
Observed MW: | 170kDa/185kDa |
Synonyms: | CPSF1, CPSF160, HSU37012, P/cl.18 |
Background: | Cleavage and polyadenylation specificity factor (CPSF) is a multisubunit complex that plays a central role in 3-prime processing of pre-mRNAs. CPSF recognizes the AAUAAA signal in the pre-mRNA and interacts with other proteins to facilitate both RNA cleavage and poly(A) synthesis. CPSF1 is the largest subunit of the CPSF complex (Murthy and Manley, 1995 [PubMed 7590244]). |
UniProt Protein Function: | Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. This subunit is involved in the RNA recognition step of the polyadenylation reaction. |
NCBI Summary: | Cleavage and polyadenylation specificity factor (CPSF) is a multisubunit complex that plays a central role in 3-prime processing of pre-mRNAs. CPSF recognizes the AAUAAA signal in the pre-mRNA and interacts with other proteins to facilitate both RNA cleavage and poly(A) synthesis. CPSF1 is the largest subunit of the CPSF complex (Murthy and Manley, 1995 [PubMed 7590244]).[supplied by OMIM, Mar 2008] |
UniProt Code: | Q10570 |
NCBI GenInfo Identifier: | 56676371 |
NCBI Gene ID: | 29894 |
NCBI Accession: | NP_037423.2 |
UniProt Secondary Accession: | Q10570,Q96AF0, |
UniProt Related Accession: | Q10570 |
Molecular Weight: | 160,884 Da |
NCBI Full Name: | cleavage and polyadenylation specificity factor subunit 1 |
NCBI Synonym Full Names: | cleavage and polyadenylation specific factor 1 |
NCBI Official Symbol: | CPSF1 |
NCBI Official Synonym Symbols: | CPSF160; P/cl.18; HSU37012 |
NCBI Protein Information: | cleavage and polyadenylation specificity factor subunit 1 |
UniProt Protein Name: | Cleavage and polyadenylation specificity factor subunit 1 |
UniProt Synonym Protein Names: | Cleavage and polyadenylation specificity factor 160 kDa subunit; CPSF 160 kDa subunit |
UniProt Gene Name: | CPSF1 |