Cell Biology Antibodies 5

Anti-CPNE3 Antibody (CAB14689)

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SKU:
CAB14689
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-CPNE3 Antibody
Antibody SKU:CAB14689
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 238-537 of human CPNE3 (NP_003900.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse
Positive Samples:OVCAR3, Mouse brain, Mouse heart, Mouse kidney
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 238-537 of human CPNE3 (NP_003900.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:EASR SSPV EFEC INEK KRQK KKSY KNSG VISV KQCE ITVE CTFL DYIM GGCQ LNFT VGVD FTGS NGDP RSPD SLHY ISPN GVNE YLTA LWSV GLVI QDYD ADKM FPAF GFGA QIPP QWQV SHEF PMNF NPSN PYCN GIQG IVEA YRSC LPQI KLYG PTNF SPII NHVA RFAA AATQ QQTA SQYF VLLI ITDG VITD LDET RQAI VNAS RLPM SIII VGVG GADF SAME FLDG DGGS LRSP LGEV AIRD IVQF VPFR QFQN APKE ALAQ CVLA EIPQ QVVG YFNT YKLL PPKN PATK QQKQ
Gene ID:8895
Uniprot:O75131
Cellular Location:Cell junction, Cell membrane, Cytoplasm, Nucleus, focal adhesion
Calculated MW:60kDa
Observed MW:60kDa
Synonyms:CPNE3, CPN3, PRO1071, copine-3
Background:Calcium-dependent membrane-binding proteins may regulate molecular events at the interface of the cell membrane and cytoplasm. This gene encodes a protein which contains two type II C2 domains in the amino-terminus and an A domain-like sequence in the carboxy-terminus. The A domain mediates interactions between integrins and extracellular ligands.
UniProt Protein Function:CPNE3: May function in membrane trafficking. Exhibits calcium- dependent phospholipid binding properties. Belongs to the copine family.
UniProt Protein Details:

Protein type:Calcium-binding; Lipid-binding

Chromosomal Location of Human Ortholog: 8q21.3

Cellular Component: cell junction; cytoplasm; cytosol; focal adhesion; nucleus; plasma membrane

Molecular Function:calcium-dependent phospholipid binding; calcium-dependent protein binding; protein binding; protein serine/threonine kinase activity; receptor tyrosine kinase binding; transporter activity

Biological Process: glycerophospholipid biosynthetic process; lipid metabolic process; positive regulation of cell migration; vesicle-mediated transport

NCBI Summary:Calcium-dependent membrane-binding proteins may regulate molecular events at the interface of the cell membrane and cytoplasm. This gene encodes a protein which contains two type II C2 domains in the amino-terminus and an A domain-like sequence in the carboxy-terminus. The A domain mediates interactions between integrins and extracellular ligands. [provided by RefSeq, Aug 2008]
UniProt Code:O75131
NCBI GenInfo Identifier:10719946
NCBI Gene ID:8895
NCBI Accession:O75131.1
UniProt Secondary Accession:O75131,Q8IYA1, A8KA47,
UniProt Related Accession:O75131
Molecular Weight:60,131 Da
NCBI Full Name:Copine-3
NCBI Synonym Full Names:copine 3
NCBI Official Symbol:CPNE3  
NCBI Official Synonym Symbols:CPN3; PRO1071  
NCBI Protein Information:copine-3
UniProt Protein Name:Copine-3
UniProt Synonym Protein Names:Copine III
Protein Family:Copine
UniProt Gene Name:CPNE3  
UniProt Entry Name:CPNE3_HUMAN
Anti-CPNE3 Antibody (CAB14689)Western blot analysis of extracts of various cell lines, using CPNE3 antibody (CAB14689) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 60s.
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