Cell Biology Antibodies 10
Anti-CPM Antibody (CAB6565)
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- SKU:
- CAB6565
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-CPM Antibody |
| Antibody SKU: | CAB6565 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 204-443 of human CPM (NP_001005502.1). |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:100 |
| Reactivity: | Human |
| Positive Samples: | HeLa |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 204-443 of human CPM (NP_001005502.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | VQAT GALY SRSL TPDD DVFQ YLAH TYAS RNPN MKKG DECK NKMN FPNG VTNG YSWY PLQG GMQD YNYI WAQC FEIT LELS CCKY PREE KLPS FWNN NKAS LIEY IKQV HLGV KGQV FDQN GNPL PNVI VEVQ DRKH ICPY RTNK YGEY YLLL LPGS YIIN VTVP GHDP HITK VIIP EKSQ NFSA LKKD ILLP FQGQ LDSI PVSN PSCP MIPL YRNL PDHS AATK PSLF LFLV SLLH IFFK |
| Gene ID: | 1368 |
| Uniprot: | P14384 |
| Cellular Location: | Cell membrane, GPI-anchor, Lipid-anchor |
| Calculated MW: | 50kDa |
| Observed MW: | 62kDa |
| Synonyms: | CPM |
| Background: | The protein encoded by this gene is a membrane-bound arginine/lysine carboxypeptidase. Its expression is associated with monocyte to macrophage differentiation. This encoded protein contains hydrophobic regions at the amino and carboxy termini and has 6 potential asparagine-linked glycosylation sites. The active site residues of carboxypeptidases A and B are conserved in this protein. Three alternatively spliced transcript variants encoding the same protein have been described for this gene. |
| UniProt Protein Function: | CPM: Specifically removes C-terminal basic residues (Arg or Lys) from peptides and proteins. It is believed to play important roles in the control of peptide hormone and growth factor activity at the cell surface, and in the membrane-localized degradation of extracellular proteins. Belongs to the peptidase M14 family. |
| UniProt Protein Details: | Protein type:EC 3.4.17.12; Protease; Membrane protein, GPI anchor Chromosomal Location of Human Ortholog: 12q14.3 Cellular Component: cell surface; plasma membrane Molecular Function:carboxypeptidase activity; zinc ion binding; metallocarboxypeptidase activity Biological Process: anatomical structure morphogenesis; proteolysis |
| NCBI Summary: | The protein encoded by this gene is a membrane-bound arginine/lysine carboxypeptidase. Its expression is associated with monocyte to macrophage differentiation. This encoded protein contains hydrophobic regions at the amino and carboxy termini and has 6 potential asparagine-linked glycosylation sites. The active site residues of carboxypeptidases A and B are conserved in this protein. Three alternatively spliced transcript variants encoding the same protein have been described for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P14384 |
| NCBI GenInfo Identifier: | 14916957 |
| NCBI Gene ID: | 1368 |
| NCBI Accession: | P14384.2 |
| UniProt Secondary Accession: | P14384,Q9H2K9, B2R800, |
| UniProt Related Accession: | P14384 |
| Molecular Weight: | 443 |
| NCBI Full Name: | Carboxypeptidase M |
| NCBI Synonym Full Names: | carboxypeptidase M |
| NCBI Official Symbol: | CPM |
| NCBI Protein Information: | carboxypeptidase M; renal carboxypeptidase; urinary carboxypeptidase B |
| UniProt Protein Name: | Carboxypeptidase M |
| Protein Family: | Carboxypeptidase |
| UniProt Gene Name: | CPM |
| UniProt Entry Name: | CBPM_HUMAN |
 | Western blot analysis of extracts of HeLa cells, using CPM Antibody (CAB6565) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 15s. |
 | Immunohistochemistry of paraffin-embedded human stomach using CPM antibody (CAB6565) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded human liver damage using CPM antibody (CAB6565) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded human esophagus using CPM antibody (CAB6565) at dilution of 1:100 (40x lens). |
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