Cell Biology Antibodies 2
Anti-CPLX1 Antibody (CAB11588)
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- SKU:
- CAB11588
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-CPLX1 Antibody |
| Antibody SKU: | CAB11588 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-134 of human CPLX1 (NP_006642.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | SH-SY5Y, Mouse eye, Rat brain, Rat eye |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-134 of human CPLX1 (NP_006642.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MEFV MKQA LGGA TKDM GKML GGDE EKDP DAAK KEEE RQEA LRQA EEER KAKY AKME AERE AVRQ GIRD KYGI KKKE EREA EAQA AMEA NSEG SLTR PKKA IPPG CGDE VEEE DESI LDTV IKYL PGPL QDML KK |
| Gene ID: | 10815 |
| Uniprot: | O14810 |
| Cellular Location: | Cytoplasm, cytosol |
| Calculated MW: | 15kDa |
| Observed MW: | 15kDa |
| Synonyms: | CPLX1, CPX-I, CPX1 |
| Background: | Proteins encoded by the complexin/synaphin gene family are cytosolic proteins that function in synaptic vesicle exocytosis. These proteins bind syntaxin, part of the SNAP receptor. The protein product of this gene binds to the SNAP receptor complex and disrupts it, allowing transmitter release. |
| UniProt Protein Function: | CPLX1: Positively regulates a late step in synaptic vesicle exocytosis. Organizes the SNAREs into a cross-linked zigzag topology that, when interposed between the vesicle and plasma membranes, is incompatible with fusion, thereby preventing SNAREs from releasing neurotransmitters until an action potential arrives at the synapse. Also involved in glucose-induced secretion of insulin by pancreatic beta-cells. Belongs to the complexin/synaphin family. |
| UniProt Protein Details: | Protein type:Vesicle Chromosomal Location of Human Ortholog: 4p16.3 Cellular Component: cytosol Biological Process: exocytosis; glutamate secretion; neurotransmitter secretion; regulation of exocytosis; synaptic transmission Disease: Wolf-hirschhorn Syndrome |
| NCBI Summary: | Proteins encoded by the complexin/synaphin gene family are cytosolic proteins that function in synaptic vesicle exocytosis. These proteins bind syntaxin, part of the SNAP receptor. The protein product of this gene binds to the SNAP receptor complex and disrupts it, allowing transmitter release. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O14810 |
| NCBI GenInfo Identifier: | 5921800 |
| NCBI Gene ID: | 10815 |
| NCBI Accession: | O14810.1 |
| UniProt Secondary Accession: | O14810,A6NI80, B2R4R5, D3DVN3, F1T0G1, |
| UniProt Related Accession: | O14810 |
| Molecular Weight: | 15kDa |
| NCBI Full Name: | Complexin-1 |
| NCBI Synonym Full Names: | complexin 1 |
| NCBI Official Symbol: | CPLX1 |
| NCBI Official Synonym Symbols: | CPX1; CPX-I |
| NCBI Protein Information: | complexin-1 |
| UniProt Protein Name: | Complexin-1 |
| UniProt Synonym Protein Names: | Complexin I; CPX I; Synaphin-2 |
| UniProt Gene Name: | CPLX1 |
 | Western blot analysis of extracts of various cell lines, using CPLX1 antibody (CAB11588) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
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