Cell Biology Antibodies 4

Anti-CPA1 Antibody (CAB13916)

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SKU:
CAB13916
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-CPA1 Antibody
Antibody SKU:CAB13916
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 111-419 of human CPA1 (NP_001859.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human
Positive Samples:
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 111-419 of human CPA1 (NP_001859.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:ARST DTFN YATY HTLE EIYD FLDL LVAE NPHL VSKI QIGN TYEG RPIY VLKF STGG SKRP AIWI DTGI HSRE WVTQ ASGV WFAK KITQ DYGQ DAAF TAIL DTLD IFLE IVTN PDGF AFTH STNR MWRK TRSH TAGS LCIG VDPN RNWD AGFG LSGA SSNP CSET YHGK FANS EVEV KSIV DFVK DHGN IKAF ISIH SYSQ LLMY PYGY KTEP VPDQ DELD QLSK AAVT ALAS LYGT KFNY GSII KAIY QASG STID WTYS QGIK YSFT FELR DTGR YGFL LPAS QIIP TAKE TWLA LLTI MEHT LNHP Y
Gene ID:1357
Uniprot:P15085
Cellular Location:Secreted
Calculated MW:47kDa
Observed MW:Refer to figures
Synonyms:CPA1, CPA
Background:This gene encodes a member of the carboxypeptidase A family of zinc metalloproteases. This enzyme is produced in the pancreas and preferentially cleaves C-terminal branched-chain and aromatic amino acids from dietary proteins. This gene and several family members are present in a gene cluster on chromosome 7. Mutations in this gene may be linked to chronic pancreatitis, while elevated protein levels may be associated with pancreatic cancer.
UniProt Protein Function:CPA1: Carboxypeptidase that catalyzes the release of a C- terminal amino acid, but has little or no action with -Asp, -Glu, -Arg, -Lys or -Pro. Belongs to the peptidase M14 family.
UniProt Protein Details:

Protein type:Secreted, signal peptide; Protease; EC 3.4.17.1; Secreted

Chromosomal Location of Human Ortholog: 7q32

Cellular Component: extracellular space

Molecular Function:zinc ion binding; metallocarboxypeptidase activity

Biological Process: proteolysis

NCBI Summary:Three different forms of human pancreatic procarboxypeptidase A have been isolated. This gene encodes a monomeric pancreatic exopeptidase involved in zymogen inhibition. [provided by RefSeq, Jan 2009]
UniProt Code:P15085
NCBI GenInfo Identifier:399196
NCBI Gene ID:1357
NCBI Accession:P15085.2
UniProt Secondary Accession:P15085,Q53XU0, Q9BS67, Q9UCF2, A4D1M1,
UniProt Related Accession:P15085
Molecular Weight:419
NCBI Full Name:Carboxypeptidase A1
NCBI Synonym Full Names:carboxypeptidase A1 (pancreatic)
NCBI Official Symbol:CPA1  
NCBI Official Synonym Symbols:CPA  
NCBI Protein Information:carboxypeptidase A1; pancreatic carboxypeptidase A
UniProt Protein Name:Carboxypeptidase A1
Protein Family:Carboxypeptidase
UniProt Gene Name:CPA1  
UniProt Entry Name:CBPA1_HUMAN
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