Name: Anti-COX8A Antibody (CAB3290)
Brand: Cell Biology Antibodies 8
SKU: CAB3290
Availability: OutOfStock

Antibody Name:	Anti-COX8A Antibody
Antibody SKU:	CAB3290
Antibody Size:	20uL, 50uL, 100uL
Application:	WB
Reactivity:	Human, Mouse
Host Species:	Rabbit
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 1-69 of human COX8A (NP_004065.1).

Application:	WB
Recommended Dilution:	WB 1:1000 - 1:2000
Reactivity:	Human, Mouse
Positive Samples:	Mouse skeletal muscle

Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 1-69 of human COX8A (NP_004065.1).
Purification Method:	Affinity purification
Storage Buffer:	Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:	IgG
Sequence:	MSVL TPLL LRGL TGSA RRLP VPRA KIHS LPPE GKLG IMEL AVGL TSCF VTFL LPAG WILS HLET YRRP E
Gene ID:	1351
Uniprot:	P10176
Cellular Location:	Mitochondrion inner membrane
Calculated MW:	7kDa
Observed MW:	8kDa

Synonyms:

COX8A, COX, COX8, COX8-2, COX8L, VIII, VIII-L

Background:

The protein encoded by this gene is the terminal enzyme of the respiratory chain, coupling the transfer of electrons from cytochrome c to molecular oxygen, with the concomitant production of a proton electrochemical gradient across the inner mitochondrial membrane. In addition to 3 mitochondrially encoded subunits, which perform the catalytic function, the eukaryotic enzyme contains nuclear-encoded smaller subunits, ranging in number from 4 in some organisms to 10 in mammals. It has been proposed that nuclear-encoded subunits may be involved in the modulation of the catalytic function. This gene encodes one of the nuclear-encoded subunits.

UniProt Protein Function:	COX8A: This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport. Belongs to the cytochrome c oxidase VIII family.
UniProt Protein Details:	Protein type:Membrane protein, integral; Energy Metabolism - oxidative phosphorylation; Mitochondrial Chromosomal Location of Human Ortholog: 11q12-q13 Cellular Component: mitochondrial inner membrane; integral to membrane Molecular Function:cytochrome-c oxidase activity Biological Process: cellular metabolic process; generation of precursor metabolites and energy; transmembrane transport
NCBI Summary:	The protein encoded by this gene is the terminal enzyme of the respiratory chain, coupling the transfer of electrons from cytochrome c to molecular oxygen, with the concomitant production of a proton electrochemical gradient across the inner mitochondrial membrane. In addition to 3 mitochondrially encoded subunits, which perform the catalytic function, the eukaryotic enzyme contains nuclear-encoded smaller subunits, ranging in number from 4 in some organisms to 10 in mammals. It has been proposed that nuclear-encoded subunits may be involved in the modulation of the catalytic function. This gene encodes one of the nuclear-encoded subunits. [provided by RefSeq, Jul 2008]
UniProt Code:	P10176
NCBI GenInfo Identifier:	117132
NCBI Gene ID:	1351
NCBI Accession:	P10176.2
UniProt Secondary Accession:	P10176,P15955,
UniProt Related Accession:	P10176
Molecular Weight:	7,579 Da
NCBI Full Name:	Cytochrome c oxidase subunit 8A, mitochondrial
NCBI Synonym Full Names:	cytochrome c oxidase subunit VIIIA (ubiquitous)
NCBI Official Symbol:	COX8A
NCBI Official Synonym Symbols:	COX; COX8; VIII; COX8L; COX8-2; VIII-L
NCBI Protein Information:	cytochrome c oxidase subunit 8A, mitochondrial; cytochrome c oxidase polypeptide VIII-liver/heart; cytochrome c oxidase subunit 8-2; cytochrome c oxidase subunit 8A (ubiquitous); cytochrome c oxidase subunit VIII
UniProt Protein Name:	Cytochrome c oxidase subunit 8A, mitochondrial
UniProt Synonym Protein Names:	Cytochrome c oxidase polypeptide VIII-liver/heart; Cytochrome c oxidase subunit 8-2
UniProt Gene Name:	COX8A
UniProt Entry Name:	COX8A_HUMAN