Cell Biology Antibodies 8

Anti-COX8A Antibody (CAB3290)

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SKU:
CAB3290
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology

Description

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Antibody Name:Anti-COX8A Antibody
Antibody SKU:CAB3290
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-69 of human COX8A (NP_004065.1).
Application:WB
Recommended Dilution:WB 1:1000 - 1:2000
Reactivity:Human, Mouse
Positive Samples:Mouse skeletal muscle
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-69 of human COX8A (NP_004065.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MSVL TPLL LRGL TGSA RRLP VPRA KIHS LPPE GKLG IMEL AVGL TSCF VTFL LPAG WILS HLET YRRP E
Gene ID:1351
Uniprot:P10176
Cellular Location:Mitochondrion inner membrane
Calculated MW:7kDa
Observed MW:8kDa
Synonyms:COX8A, COX, COX8, COX8-2, COX8L, VIII, VIII-L
Background:The protein encoded by this gene is the terminal enzyme of the respiratory chain, coupling the transfer of electrons from cytochrome c to molecular oxygen, with the concomitant production of a proton electrochemical gradient across the inner mitochondrial membrane. In addition to 3 mitochondrially encoded subunits, which perform the catalytic function, the eukaryotic enzyme contains nuclear-encoded smaller subunits, ranging in number from 4 in some organisms to 10 in mammals. It has been proposed that nuclear-encoded subunits may be involved in the modulation of the catalytic function. This gene encodes one of the nuclear-encoded subunits.
UniProt Protein Function:COX8A: This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport. Belongs to the cytochrome c oxidase VIII family.
UniProt Protein Details:

Protein type:Membrane protein, integral; Energy Metabolism - oxidative phosphorylation; Mitochondrial

Chromosomal Location of Human Ortholog: 11q12-q13

Cellular Component: mitochondrial inner membrane; integral to membrane

Molecular Function:cytochrome-c oxidase activity

Biological Process: cellular metabolic process; generation of precursor metabolites and energy; transmembrane transport

NCBI Summary:The protein encoded by this gene is the terminal enzyme of the respiratory chain, coupling the transfer of electrons from cytochrome c to molecular oxygen, with the concomitant production of a proton electrochemical gradient across the inner mitochondrial membrane. In addition to 3 mitochondrially encoded subunits, which perform the catalytic function, the eukaryotic enzyme contains nuclear-encoded smaller subunits, ranging in number from 4 in some organisms to 10 in mammals. It has been proposed that nuclear-encoded subunits may be involved in the modulation of the catalytic function. This gene encodes one of the nuclear-encoded subunits. [provided by RefSeq, Jul 2008]
UniProt Code:P10176
NCBI GenInfo Identifier:117132
NCBI Gene ID:1351
NCBI Accession:P10176.2
UniProt Secondary Accession:P10176,P15955,
UniProt Related Accession:P10176
Molecular Weight:7,579 Da
NCBI Full Name:Cytochrome c oxidase subunit 8A, mitochondrial
NCBI Synonym Full Names:cytochrome c oxidase subunit VIIIA (ubiquitous)
NCBI Official Symbol:COX8A  
NCBI Official Synonym Symbols:COX; COX8; VIII; COX8L; COX8-2; VIII-L  
NCBI Protein Information:cytochrome c oxidase subunit 8A, mitochondrial; cytochrome c oxidase polypeptide VIII-liver/heart; cytochrome c oxidase subunit 8-2; cytochrome c oxidase subunit 8A (ubiquitous); cytochrome c oxidase subunit VIII
UniProt Protein Name:Cytochrome c oxidase subunit 8A, mitochondrial
UniProt Synonym Protein Names:Cytochrome c oxidase polypeptide VIII-liver/heart; Cytochrome c oxidase subunit 8-2
UniProt Gene Name:COX8A  
UniProt Entry Name:COX8A_HUMAN
Anti-COX8A Antibody (CAB3290)Western blot analysis of extracts of mouse skeletal muscle, using COX8A antibody (CAB3290).
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