Cell Biology Antibodies 6

Anti-COX6C Antibody (CAB16250)

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SKU:
CAB16250
Product Type:
Antibody
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-COX6C Antibody
Antibody SKU:CAB16250
Antibody Size:20uL, 50uL, 100uL
Application:WB IF
Reactivity:Mouse
Host Species:Rabbit
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 1-75 of human COX6C (NP_004365.1).
Application:WB IF
Recommended Dilution:WB 1:500 - 1:2000 IF 1:50 - 1:200
Reactivity:Mouse
Positive Samples:
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 1-75 of human COX6C (NP_004365.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MAPE VLPK PRMR GLLA RRLR NHMA VAFV LSLG VAAL YKFR VADQ RKKA YADF YRNY DVMK DFEE MRKA GIFQ SVK
Gene ID:1345
Uniprot:P09669
Cellular Location:
Calculated MW:8kDa
Observed MW:Refer to figures
Synonyms:COX6C
Background:Cytochrome c oxidase, the terminal enzyme of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. It is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may be involved in the regulation and assembly of the complex. This nuclear gene encodes subunit VIc, which has 77% amino acid sequence identity with mouse subunit VIc. This gene is up-regulated in prostate cancer cells. A pseudogene has been found on chromosomes 16p12.
UniProt Protein Function:COX6C: This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport. Belongs to the cytochrome c oxidase subunit 6c family.
UniProt Protein Details:

Protein type:Membrane protein, integral; Energy Metabolism - oxidative phosphorylation; Oxidoreductase; Mitochondrial; EC 1.9.3.1

Chromosomal Location of Human Ortholog: 8q22.2

Cellular Component: mitochondrial inner membrane; mitochondrion

Biological Process: generation of precursor metabolites and energy; mitochondrial electron transport, cytochrome c to oxygen

NCBI Summary:Cytochrome c oxidase, the terminal enzyme of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. It is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may be involved in the regulation and assembly of the complex. This nuclear gene encodes subunit VIc, which has 77% amino acid sequence identity with mouse subunit VIc. This gene is up-regulated in prostate cancer cells. A pseudogene has been found on chromosomes 16p12. [provided by RefSeq, Jul 2010]
UniProt Code:P09669
NCBI GenInfo Identifier:1352175
NCBI Gene ID:1345
NCBI Accession:P09669.2
UniProt Secondary Accession:P09669,B2R4D7,
UniProt Related Accession:P09669
Molecular Weight:8,781 Da
NCBI Full Name:Cytochrome c oxidase subunit 6C
NCBI Synonym Full Names:cytochrome c oxidase subunit 6C
NCBI Official Symbol:COX6C  
NCBI Protein Information:cytochrome c oxidase subunit 6C
UniProt Protein Name:Cytochrome c oxidase subunit 6C
UniProt Synonym Protein Names:Cytochrome c oxidase polypeptide VIc
Protein Family:Cytochrome c oxidase
UniProt Gene Name:COX6C  
UniProt Entry Name:COX6C_HUMAN
Anti-COX6C Antibody (CAB16250)Immunofluorescence analysis of NIH/3T3 cells using COX6C antibody (CAB16250) at dilution of 1:100. Blue: DAPI for nuclear staining.
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