Cell Biology Antibodies 18
Anti-COX4I2 Antibody (CAB18354)
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- SKU:
- CAB18354
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-COX4I2 Antibody |
| Antibody SKU: | CAB18354 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant protein of human COX4I2. |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: |
| Immunogen: | Recombinant protein of human COX4I2. |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 84701 |
| Uniprot: | Q96KJ9 |
| Cellular Location: | |
| Calculated MW: | 170kDa |
| Observed MW: | Refer to figures |
| Synonyms: | COX4, COX4-2, COX4B, COX4L2, COXIV-2, dJ857M17.2, COX4I2 |
| Background: |
| UniProt Protein Function: | COX4I2: This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport. Defects in COX4I2 are the cause of exocrine pancreatic insufficiency dyserythropoietic anemia and calvarial hyperostosis (EPIDACH). Patients present with pancreatic insufficiency, intestinal malabsorption, failure to thrive, and anemia soon after birth. Belongs to the cytochrome c oxidase IV family. |
| UniProt Protein Details: | Protein type:Mitochondrial; Oxidoreductase Chromosomal Location of Human Ortholog: 20q11.21 Cellular Component: mitochondrial respiratory chain complex IV Molecular Function:cytochrome-c oxidase activity Biological Process: mitochondrial electron transport, cytochrome c to oxygen Disease: Exocrine Pancreatic Insufficiency, Dyserythropoietic Anemia, And Calvarial Hyperostosis |
| NCBI Summary: | Cytochrome c oxidase (COX), the terminal enzyme of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. It is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may be involved in the regulation and assembly of the complex. This nuclear gene encodes isoform 2 of subunit IV. Isoform 1 of subunit IV is encoded by a different gene, however, the two genes show a similar structural organization. Subunit IV is the largest nuclear encoded subunit which plays a pivotal role in COX regulation. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q96KJ9 |
| NCBI GenInfo Identifier: | 73620953 |
| NCBI Gene ID: | 84701 |
| NCBI Accession: | Q96KJ9.2 |
| UniProt Secondary Accession: | Q96KJ9,Q6GTF4, Q9H0Z4, |
| UniProt Related Accession: | Q96KJ9 |
| Molecular Weight: | 20,010 Da |
| NCBI Full Name: | Cytochrome c oxidase subunit 4 isoform 2, mitochondrial |
| NCBI Synonym Full Names: | cytochrome c oxidase subunit 4I2 |
| NCBI Official Symbol: | COX4I2 |
| NCBI Official Synonym Symbols: | COX4; COX4B; COX4-2; COX4L2; COXIV-2; dJ857M17.2 |
| NCBI Protein Information: | cytochrome c oxidase subunit 4 isoform 2, mitochondrial |
| UniProt Protein Name: | Cytochrome c oxidase subunit 4 isoform 2, mitochondrial |
| UniProt Synonym Protein Names: | Cytochrome c oxidase subunit IV isoform 2; COX IV-2 |
| UniProt Gene Name: | COX4I2 |
| UniProt Entry Name: | COX42_HUMAN |
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