Metabolism Antibodies 3
Anti-COX1 Antibody (CAB4301)
- SKU:
- CAB4301
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Metabolism
Description
| Antibody Name: | Anti-COX1 Antibody |
| Antibody SKU: | CAB4301 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human COX1 |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HeLa, Mouse lung, Mouse liver, Rat kidney |
| Immunogen: | A synthesized peptide derived from human COX1 |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 5742 |
| Uniprot: | P23219 |
| Cellular Location: | |
| Calculated MW: | 69kDa |
| Observed MW: | 65KDa/72KDa |
| Synonyms: | COX1, COX3, PCOX1, PES-1, PGG/HS, PGHS-1, PGHS1, PHS1, PTGHS |
| Background: | This is one of two genes encoding similar enzymes that catalyze the conversion of arachinodate to prostaglandin. The encoded protein regulates angiogenesis in endothelial cells, and is inhibited by nonsteroidal anti-inflammatory drugs such as aspirin. Based on its ability to function as both a cyclooxygenase and as a peroxidase, the encoded protein has been identified as a moonlighting protein. The protein may promote cell proliferation during tumor progression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014] |
| UniProt Protein Function: | COX-1: May play an important role in regulating or promoting cell proliferation in some normal and neoplastically transformed cells. Homodimer. Belongs to the prostaglandin G/H synthase family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:EC 1.14.99.1; Lipid Metabolism - arachidonic acid; Oxidoreductase Chromosomal Location of Human Ortholog: 9q32-q33.3 Cellular Component: endoplasmic reticulum membrane; photoreceptor outer segment; intracellular membrane-bound organelle; cytoplasm; nucleus Molecular Function:prostaglandin-endoperoxide synthase activity; peroxidase activity; dioxygenase activity; metal ion binding; heme binding Biological Process: regulation of blood pressure; xenobiotic metabolic process; cyclooxygenase pathway; arachidonic acid metabolic process; response to oxidative stress; lipid metabolic process; prostaglandin biosynthetic process; inflammatory response; regulation of cell proliferation |
| NCBI Summary: | This is one of two genes encoding similar enzymes that catalyze the conversion of arachinodate to prostaglandin. The encoded protein regulates angiogenesis in endothelial cells, and is inhibited by nonsteroidal anti-inflammatory drugs such as aspirin. Based on its ability to function as both a cyclooxygenase and as a peroxidase, the encoded protein has been identified as a moonlighting protein. The protein may promote cell proliferation during tumor progression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014] |
| UniProt Code: | P23219 |
| NCBI GenInfo Identifier: | 317373262 |
| NCBI Gene ID: | 5742 |
| NCBI Accession: | P23219.2 |
| UniProt Secondary Accession: | P23219,Q15122, Q3HY28, Q3HY29, Q5T7T6, Q5T7T7, Q5T7T8 A8K1V7, B4DHQ2, B4E2S5, |
| UniProt Related Accession: | P23219 |
| Molecular Weight: | 72,010 Da |
| NCBI Full Name: | Prostaglandin G/H synthase 1 |
| NCBI Synonym Full Names: | prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) |
| NCBI Official Symbol: | PTGS1 |
| NCBI Official Synonym Symbols: | COX1; COX3; PHS1; PCOX1; PES-1; PGHS1; PTGHS; PGG/HS; PGHS-1 |
| NCBI Protein Information: | prostaglandin G/H synthase 1; PGH synthase 1; cyclooxygenase-1; prostaglandin H2 synthase 1 |
| UniProt Protein Name: | Prostaglandin G/H synthase 1 |
| UniProt Synonym Protein Names: | Cyclooxygenase-1; COX-1; Prostaglandin H2 synthase 1; PGH synthase 1; PGHS-1; PHS 1; Prostaglandin-endoperoxide synthase 1 |
| Protein Family: | Cox1 intron-like protein |
| UniProt Gene Name: | PTGS1 |
| UniProt Entry Name: | PGH1_HUMAN |
 | Western blot - COX1 Rabbit mAb (CAB4301) |
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