Cell Biology Antibodies 16
Anti-COX IV Antibody (CAB11631)
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- SKU:
- CAB11631
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Monoclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-COX IV Antibody |
| Antibody SKU: | CAB11631 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human COX IV |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HeLa, MCF7, Mouse brain, Mouse heart, Rat heart |
| Immunogen: | A synthesized peptide derived from human COX IV |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 1327 |
| Uniprot: | P13073 |
| Cellular Location: | |
| Calculated MW: | 17kDa |
| Observed MW: | 17KDa |
 | Western blot - COX IV Rabbit mAb (CAB11631) |
| Synonyms: | COX IV-1, COX4, COX4-1, COXIV, COXIV-1 |
| Background: | Cytochrome c oxidase (COX) is the terminal enzyme of the mitochondrial respiratory chain. It is a multi-subunit enzyme complex that couples the transfer of electrons from cytochrome c to molecular oxygen and contributes to a proton electrochemical gradient across the inner mitochondrial membrane. The complex consists of 13 mitochondrial- and nuclear-encoded subunits. The mitochondrially-encoded subunits perform the electron transfer and proton pumping activities. The functions of the nuclear-encoded subunits are unknown but they may play a role in the regulation and assembly of the complex. This gene encodes the nuclear-encoded subunit IV isoform 1 of the human mitochondrial respiratory chain enzyme. It is located at the 3' of the NOC4 (neighbor of COX4) gene in a head-to-head orientation, and shares a promoter with it. Pseudogenes related to this gene are located on chromosomes 13 and 14. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016] |
| UniProt Protein Function: | COX4I1: This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport. Ubiquitous. Belongs to the cytochrome c oxidase IV family. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Energy Metabolism - oxidative phosphorylation; Mitochondrial; EC 1.9.3.1; Oxidoreductase Chromosomal Location of Human Ortholog: 16q24.1 Cellular Component: membrane; mitochondrial inner membrane; mitochondrial respiratory chain complex IV; mitochondrion; nucleus Molecular Function:protein binding Biological Process: generation of precursor metabolites and energy; mitochondrial electron transport, cytochrome c to oxygen |
| NCBI Summary: | Cytochrome c oxidase (COX) is the terminal enzyme of the mitochondrial respiratory chain. It is a multi-subunit enzyme complex that couples the transfer of electrons from cytochrome c to molecular oxygen and contributes to a proton electrochemical gradient across the inner mitochondrial membrane. The complex consists of 13 mitochondrial- and nuclear-encoded subunits. The mitochondrially-encoded subunits perform the electron transfer and proton pumping activities. The functions of the nuclear-encoded subunits are unknown but they may play a role in the regulation and assembly of the complex. This gene encodes the nuclear-encoded subunit IV isoform 1 of the human mitochondrial respiratory chain enzyme. It is located at the 3' of the NOC4 (neighbor of COX4) gene in a head-to-head orientation, and shares a promoter with it. Pseudogenes related to this gene are located on chromosomes 13 and 14. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016] |
| UniProt Code: | P13073 |
| NCBI GenInfo Identifier: | 117086 |
| NCBI Gene ID: | 1327 |
| NCBI Accession: | P13073.1 |
| UniProt Secondary Accession: | P13073,Q6P666, B2R4J2, D3DUM7, |
| UniProt Related Accession: | P13073 |
| Molecular Weight: | 19,577 Da |
| NCBI Full Name: | Cytochrome c oxidase subunit 4 isoform 1, mitochondrial |
| NCBI Synonym Full Names: | cytochrome c oxidase subunit 4I1 |
| NCBI Official Symbol: | COX4I1 |
| NCBI Official Synonym Symbols: | COX4; COXIV; COX4-1; COXIV-1; COX IV-1 |
| NCBI Protein Information: | cytochrome c oxidase subunit 4 isoform 1, mitochondrial |
| UniProt Protein Name: | Cytochrome c oxidase subunit 4 isoform 1, mitochondrial |
| UniProt Synonym Protein Names: | Cytochrome c oxidase polypeptide IV; Cytochrome c oxidase subunit IV isoform 1; COX IV-1 |
| Protein Family: | Cytochrome c oxidase |
| UniProt Gene Name: | COX4I1 |
| UniProt Entry Name: | COX41_HUMAN |
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