Cell Biology Antibodies 9
Anti-COTL1 Antibody (CAB4550)
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- SKU:
- CAB4550
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- COTL1
- Synonyms:
- CLP
- Research Area:
- Cell Biology
Description
| Product Name: | COTL1 Rabbit pAb |
| Product Code: | CAB4550 |
| Size: | 20uL, 50uL, 100uL |
| Synonyms: | COTL1, CLP |
| Applications: | WB, IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-142 of human COTL1 (NP_066972.1). |
| Applications: | WB, IHC |
| Recommended Dilutions: | WB 1:500 - 1:2000 IHC 1:50 - 1:100 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | Jurkat, 293T, U-251MG, HeLa, Mouse lung, Mouse kidney, Mouse spleen |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-142 of human COTL1 (NP_066972.1). |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MATK IDKE ACRA AYNL VRDD GSAV IWVT FKYD GSTI VPGE QGAE YQHF IQQC TDDV RLFA FVRF TTGD AMSK RSKF ALIT WIGE NVSG LQRA KTGT DKTL VKEV VQNF AKEF VISD RKEL EEDF IKSE LKKA GGAN YDAQ TE |
| Gene ID: | 23406 |
| Uniprot: | Q14019 |
| Cellular Location: | Cytoplasm, Nucleus membrane, Peripheral membrane protein, cytoskeleton |
| Calculated MW: | 15kDa |
| Observed MW: | 14kDa |
| UniProt Protein Function: | COTL1: Binds to F-actin in a calcium-independent manner. Has no direct effect on actin depolymerization. Belongs to the actin-binding proteins ADF family. Coactosin subfamily. |
| UniProt Protein Details: | Protein type:Actin-binding Chromosomal Location of Human Ortholog: 16q24.1 Cellular Component: nuclear membrane; cytoskeleton; cytoplasm Molecular Function:protein binding; enzyme binding; actin binding Biological Process: defense response to fungus |
| NCBI Summary: | This gene encodes one of the numerous actin-binding proteins which regulate the actin cytoskeleton. This protein binds F-actin, and also interacts with 5-lipoxygenase, which is the first committed enzyme in leukotriene biosynthesis. Although this gene has been reported to map to chromosome 17 in the Smith-Magenis syndrome region, the best alignments for this gene are to chromosome 16. The Smith-Magenis syndrome region is the site of two related pseudogenes. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q14019 |
| NCBI GenInfo Identifier: | 21759076 |
| NCBI Gene ID: | 23406 |
| NCBI Accession: | Q14019.3 |
| UniProt Related Accession: | Q14019 |
| Molecular Weight: | |
| NCBI Full Name: | Coactosin-like protein |
| NCBI Synonym Full Names: | coactosin like F-actin binding protein 1 |
| NCBI Official Symbol: | COTL1 |
| NCBI Official Synonym Symbols: | CLP |
| NCBI Protein Information: | coactosin-like protein |
| UniProt Protein Name: | Coactosin-like protein |
| Protein Family: | Coactosin-like protein |
| UniProt Gene Name: | COTL1 |
| UniProt Entry Name: | COTL1_HUMAN |
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