Cell Biology Antibodies 5

Anti-CORO2A Antibody (CAB14469)

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SKU:
CAB14469
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-CORO2A Antibody
Antibody SKU:CAB14469
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 376-525 of human CORO2A (NP_003380.3).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:HT-29, OVCAR3, Mouse eye, Rat eye
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 376-525 of human CORO2A (NP_003380.3).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:QPSL TAQE WLSG MNRD PILV SLRP GSEL LRPH PLPA ERPI FNSM APAS PRLL NQTE KLAA EDGW RSSS LLEE KMPR WAAE HRLE EKKT WLTN GFDV FECP PPKT ENEL LQMF YRQQ EEIR RLRE LLTQ REVQ AKQL ELEI KNLR MGSE QL
Gene ID:7464
Uniprot:Q92828
Cellular Location:
Calculated MW:59kDa
Observed MW:60kDa
Synonyms:CORO2A, CLIPINB, IR10, WDR2
Background:This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein contains 5 WD repeats, and has a structural similarity with actin-binding proteins: the D. discoideum coronin and the human p57 protein, suggesting that this protein may also be an actin-binding protein that regulates cell motility. Alternative splicing of this gene generates 2 transcript variants.
UniProt Protein Function:coronin 2A: a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein contains 5 WD repeats, and has a structural similarity with actin-binding proteins: the D. discoideum coronin and the human p57 protein, suggesting that this protein may also be an actin-binding protein that regulates cell motility. Alternative splicing of this gene generates 2 transcript variants. [provided by RefSeq, Jul 2008]
UniProt Protein Details:

Protein type:Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 9q22.3

Cellular Component: actin cytoskeleton; transcriptional repressor complex

Molecular Function:actin filament binding

Biological Process: actin cytoskeleton organization and biogenesis

NCBI Summary:This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein contains 5 WD repeats, and has a structural similarity with actin-binding proteins: the D. discoideum coronin and the human p57 protein, suggesting that this protein may also be an actin-binding protein that regulates cell motility. Alternative splicing of this gene generates 2 transcript variants. [provided by RefSeq, Jul 2008]
UniProt Code:Q92828
NCBI GenInfo Identifier:28381354
NCBI Gene ID:7464
NCBI Accession:Q92828.2
UniProt Secondary Accession:Q92828,Q5TBR5, Q92829, Q9BWS5,
UniProt Related Accession:Q92828
Molecular Weight:59,763 Da
NCBI Full Name:Coronin-2A
NCBI Synonym Full Names:coronin 2A
NCBI Official Symbol:CORO2A  
NCBI Official Synonym Symbols:IR10; WDR2; CLIPINB  
NCBI Protein Information:coronin-2A
UniProt Protein Name:Coronin-2A
UniProt Synonym Protein Names:IR10; WD repeat-containing protein 2
Protein Family:Coronin
UniProt Gene Name:CORO2A  
UniProt Entry Name:COR2A_HUMAN
Anti-CORO2A Antibody (CAB14469)Western blot analysis of extracts of various cell lines, using CORO2A antibody (CAB14469) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s.
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