Signal Transduction Antibodies 1
Anti-CORO1B Antibody (CAB14593)
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- SKU:
- CAB14593
- Product Type:
- Antibody
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Description
| Antibody Name: | Anti-CORO1B Antibody |
| Antibody SKU: | CAB14593 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 380-489 of human CORO1B (NP_065174.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Rat |
| Positive Samples: | Rat kidney |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 380-489 of human CORO1B (NP_065174.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | VSGR DADP ILIS LREA YVPS KQRD LKIS RRNV LSDS RPAM APGS SHLG APAS TTTA ADAT PSGS LARA GEAG KLEE VMQE LRAL RALV KEQG DRIC RLEE QLGR MENG DA |
| Gene ID: | 57175 |
| Uniprot: | Q9BR76 |
| Cellular Location: | Cytoplasm, cytoskeleton |
| Calculated MW: | 54kDa |
| Observed MW: | 54kDa |
| Synonyms: | CORO1B, CORONIN-2 |
| Background: |
| UniProt Protein Function: | coronin 1B: an actin-binding protein that regulates leading edge dynamics and cell motility in fibroblasts. Coordinates the Arp2/3 complex (includes ACTR2, ARPC1B and ARPC2) cofilin activities at the leading edge. Localized to the leading edge in fibroblasts and weakly along actin stress fibers. Phosphorylation by PKC regulates the interaction with the Arp2/3 complex and cell motility in fibroblasts. Belongs to the WD repeat coronin family. |
| UniProt Protein Details: | Protein type:Actin-binding; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 11q13.2 Cellular Component: actin filament; cytoplasm; cytosol; focal adhesion; lamellipodium; leading edge; perinuclear region of cytoplasm; plasma membrane; stress fiber Molecular Function:actin filament binding; identical protein binding; protein binding Biological Process: actin cytoskeleton organization and biogenesis; actin filament bundle formation; cell migration; ruffle organization and biogenesis; wound healing |
| NCBI Summary: | Members of the coronin family, such as CORO1B, are WD repeat-containing actin-binding proteins that regulate cell motility (Cai et al., 2005 [PubMed 16027158]).[supplied by OMIM, Mar 2008] |
| UniProt Code: | Q9BR76 |
| NCBI GenInfo Identifier: | 21263481 |
| NCBI Gene ID: | 57175 |
| NCBI Accession: | Q9BR76.1 |
| UniProt Secondary Accession: | Q9BR76,B2RD45, |
| UniProt Related Accession: | Q9BR76 |
| Molecular Weight: | 54,235 Da |
| NCBI Full Name: | Coronin-1B |
| NCBI Synonym Full Names: | coronin 1B |
| NCBI Official Symbol: | CORO1B |
| NCBI Official Synonym Symbols: | CORONIN-2 |
| NCBI Protein Information: | coronin-1B |
| UniProt Protein Name: | Coronin-1B |
| UniProt Synonym Protein Names: | Coronin-2 |
| Protein Family: | Coronin |
| UniProt Gene Name: | CORO1B |
| UniProt Entry Name: | COR1B_HUMAN |
 | Western blot analysis of extracts of rat kidney, using CORO1B antibody (CAB14593) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s. |
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