Cell Biology Antibodies 12
Anti-Cornulin Antibody (CAB8762)
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- SKU:
- CAB8762
- Product Type:
- Antibody
- Applications:
- WB
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-Cornulin Antibody |
| Antibody SKU: | CAB8762 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 396-495 of human CRNN (NP_057274.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:1000 |
| Reactivity: | Human, Mouse |
| Positive Samples: | HeLa, TE-1, 293T, HepG2, Mouse kidney |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 396-495 of human CRNN (NP_057274.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | GETV PGGQ AQTG ASTE SGRQ EWSS THPR RCVT EGQG DRQP TVVG EEWV DDHS RETV ILRL DQGN LHTS VSSA QGQD AAQS EEKR GITA RELY SYLR STKP |
| Gene ID: | 49860 |
| Uniprot: | Q9UBG3 |
| Cellular Location: | Cytoplasm |
| Calculated MW: | 53kDa |
| Observed MW: | 60kDa |
| Synonyms: | CRNN, C1orf10, DRC1, PDRC1, SEP53, cornulin |
| Background: | This gene encodes a member of the 'fused gene' family of proteins, which contain N-terminus EF-hand domains and multiple tandem peptide repeats. The encoded protein contains two EF-hand Ca2+ binding domains in its N-terminus and two glutamine- and threonine-rich 60 amino acid repeats in its C-terminus. This gene, also known as squamous epithelial heat shock protein 53, may play a role in the mucosal/epithelial immune response and epidermal differentiation. |
| UniProt Protein Function: | CRNN: Survival factor that participates in the clonogenicity of squamous esophageal epithelium cell lines, attenuates deoxycholic acid (DCA)-induced apoptotic cell death and release of calcium. When overexpressed in oral squamous carcinom cell lines, regulates negatively cell proliferation by the induction of G1 arrest. Belongs to the S100-fused protein family. |
| UniProt Protein Details: | Chromosomal Location of Human Ortholog: 1q21 Cellular Component: cytoplasm; membrane Molecular Function:calcium ion binding Biological Process: cell-cell adhesion; response to heat |
| NCBI Summary: | This gene encodes a member of the "fused gene" family of proteins, which contain N-terminus EF-hand domains and multiple tandem peptide repeats. The encoded protein contains two EF-hand Ca2+ binding domains in its N-terminus and two glutamine- and threonine-rich 60 amino acid repeats in its C-terminus. This gene, also known as squamous epithelial heat shock protein 53, may play a role in the mucosal/epithelial immune response and epidermal differentiation. [provided by RefSeq, Jan 2009] |
| UniProt Code: | Q9UBG3 |
| NCBI GenInfo Identifier: | 7706635 |
| NCBI Gene ID: | 49860 |
| NCBI Accession: | NP_057274.1 |
| UniProt Secondary Accession: | Q9UBG3,Q8N613, B2RE60, |
| UniProt Related Accession: | Q9UBG3 |
| Molecular Weight: | 53,533 Da |
| NCBI Full Name: | cornulin |
| NCBI Synonym Full Names: | cornulin |
| NCBI Official Symbol: | CRNN |
| NCBI Official Synonym Symbols: | DRC1; PDRC1; SEP53; C1orf10 |
| NCBI Protein Information: | cornulin |
| UniProt Protein Name: | Cornulin |
| UniProt Synonym Protein Names: | 53 kDa putative calcium-binding protein; 53 kDa squamous epithelial-induced stress protein; 58 kDa heat shock protein; Squamous epithelial heat shock protein 53; Tumor-related protein |
| Protein Family: | Cornulin |
| UniProt Gene Name: | CRNN |
| UniProt Entry Name: | CRNN_HUMAN |
 | Western blot analysis of extracts of various cell lines, using CRNN antibody (CAB8762) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s. |
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